Antibacterial osteogenesis-promoting rubidium titanium tantalum composite material and preparation method and application thereof

A composite material, bone-promoting technology, used in medical science, prosthesis, tissue regeneration, etc., can solve the problems of poor biological activity, surgical failure, poor antibacterial properties, etc., achieve good biocompatibility, and solve the incompatibility of biocompatibility. The effect of good and wide application prospects

Active Publication Date: 2019-09-06
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems in the prior art that the medical titanium-tantalum composite material has poor antibacterial properties and poor biological activity, and it is easy to cause operation failure in actual clinical application, the purpose of the present invention is to provide an antibacterial material with excellent mechanical properties, biological activity and antibacterial properties. Promoting bone-containing rubidium-titanium-tantalum composite material and its preparation method and application

Method used

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  • Antibacterial osteogenesis-promoting rubidium titanium tantalum composite material and preparation method and application thereof
  • Antibacterial osteogenesis-promoting rubidium titanium tantalum composite material and preparation method and application thereof
  • Antibacterial osteogenesis-promoting rubidium titanium tantalum composite material and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0047] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then place the titanium-tantalum alloy powder in a cold isostatic press for compression molding, and the compression pressure is 200MPa , the pressing time is 4min, and then the pressed green body is sintered in vacuum sintering, and the vacuum degree is controlled to be 10 -4 Pa, the vacuum sintering temperature is 1200°C, the sintering time is 2h, and the heating rate is 45°C / min.

[0048] The titanium-tantalum composite material is subjected to sandblasting treatment, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution is composed of hydrochloric acid (mass fraction: 38% to write the specific value), sulfuric acid (mass fraction: 96% to write the specific value ) mixed with water in a volume ratio of 1:1:1.17. Put the acid-treated titanium-tantalum composite material in 4M ...

Embodiment 2

[0077] Prepare titanium-tantalum alloy powder, wherein in the titanium-tantalum alloy powder, according to the atomic ratio, titanium: tantalum = 1:20; then place the titanium-tantalum alloy powder in a cold isostatic press for compression molding, and the compression pressure is 180MPa , the pressing time is 3min, and then the pressed green body is sintered in vacuum sintering, and the vacuum degree is controlled to be 10 -4 Pa, the vacuum sintering temperature is 1300°C, the sintering time is 2h, and the heating rate is 50°C / min.

[0078] The titanium-tantalum composite material was sandblasted, and then placed in an acid solution for acid treatment at 65°C for 24 hours, wherein the acid solution was composed of hydrochloric acid (mass fraction: 37%), sulfuric acid (mass fraction: 95%) and water in a volume ratio of 1:1:1.4 mixed to obtain. Put the acid-treated titanium-tantalum composite material in 5M sodium hydroxide solution, and perform alkali heat treatment at 60°C fo...

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Abstract

The invention discloses an antibacterial osteogenesis-promoting rubidium titanium tantalum composite material and a preparation method thereof. The preparation method includes: performing sand blasting, acid treatment and alkali-heat treatment on a titanium tantalum composite material synthesized by cold isostatic pressing and vacuum sintering to modify the surface of the titanium tantalum composite material, doping rubidium salt into the surface of the titanium tantalum composite material after surface modifying through ion exchange, and sintering at high temperature to obtain the antibacterial osteogenesis-promoting rubidium titanium tantalum composite material. The rubidium titanium tantalum composite material has good antibacterial performance and biocompatibility, is free of cytotoxicity, can promote cell proliferation, has good effect of inducing preosteoblast osteogenesis differentiation, can effectively solve the problems that bone repair materials are prone to being affected with bacteria during clinical application and an implanted material is poor in compatibility with human body and has wide application prospect in clinical bone repair.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an antibacterial bone-promoting composite material containing rubidium, titanium and tantalum, a preparation method and application thereof. Background technique [0002] Knee osteoarthritis, hip fractures, and spinal degenerative diseases are all orthopedic diseases with a high incidence rate, and with the aging of the population, the incidence rate of the disease is increasing and younger. Titanium-tantalum composite materials are widely used in the field of clinical orthopedics because of their good mechanical properties, excellent biocompatibility and low cost. For example, joint replacement, spinal internal fixation and other common fracture treatment methods require the use of titanium-tantalum composite materials. material as a bone replacement material. However, since the titanium-tantalum composite material is a biologically inert material, the combinatio...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/54A61L27/56C22C1/04C22C27/02
CPCA61L27/427A61L27/54A61L27/56A61L2300/102A61L2300/404A61L2430/02C22C1/045C22C27/02
Inventor 刘咏陈曼可谭彦妮黄千里
Owner CENT SOUTH UNIV
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