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Application of vanillic acid in inhibiting growth of multiple drug-resistant enterobacter cloacae

A technology of Enterobacter cloacae and Enterobacter cloacae, applied in the field of medicine, to achieve the effect of solving the problem of drug-resistant infection, reducing the fatality rate, and having wide application value

Active Publication Date: 2019-09-10
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no literature report that vanillic acid has antibacterial effect on multi-drug resistant Enterobacter cloacae

Method used

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  • Application of vanillic acid in inhibiting growth of multiple drug-resistant enterobacter cloacae
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  • Application of vanillic acid in inhibiting growth of multiple drug-resistant enterobacter cloacae

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Embodiment Construction

[0016] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0017] 1. Drug susceptibility test of Enterobacter cloacae

[0018] The present invention uses human-source Enterobacter cloacae as the starting strain (the strain sample is taken from Ningbo Women and Children's Hospital), and selects cefazolin, cefotaxime, bromogmentine, meropenem, ofloxacin, levofloxacin, and ciprofloxacin Antimicrobial susceptibility tests were performed on 16 commonly used antibiotics, including floxacin, cefoxitin, minocycline, imipenem, piperacillin, azithromycin, nitrofurantoin, and gentamicin.

[0019] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of ba...

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Abstract

The invention discloses application of vanillic acid in inhibiting the growth of multiple drug-resistant enterobacter cloacae. The method comprises the steps of determining the drug resistance of enterobacter cloacae to antibiotics by means of a paper sheet diffusion approach; determining that the minimum bactericidal concentration and minimum bacteriostatic concentration of the vanillic acid on multiple drug-resistant enterobacter cloacae are 1.6 mg / mL and 1.2 mg / mL respectively by means of a double dilution approach and an agar diffusion approach. It is disclosed that the non-antibiotic compound vanillic acid has an inhibition effect on multiple drug-resistant enterobacter cloacae, and the method has a high application value in the field of medicine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of vanillic acid in inhibiting the growth of multidrug-resistant Enterobacter cloacae. Background technique [0002] Enterobacter cloacae is an Enterobacteriaceae bacterium that widely exists in the intestines of animals and humans, and is a common pathogenic bacteria in hospital-acquired infections (Ning Xingwang, Zhu Huibin, Kuang Min, Xie Xiaobing, Qian Chun. 107 strains of Enterobacter cloacae produced Detection of ESBLs and AmpC enzymes and analysis of drug resistance [J]. Practical Preventive Medicine, 2018, 25(05): 534-537.), can cause multi-system infections, respiratory tract infection is the most common, and can also cause sepsis, urinary tract infection infections, wound infections, and urinary tract infections. With the overuse and abuse of antibiotics, the extensive use of immunosuppressants, chemotherapy drugs, and various invasions, the clinical isolation r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P31/04
CPCA61K31/192A61P31/04
Inventor 钱卫东刘淼王婷沈兰芳张家宁杨敏孙照欢付玉婷
Owner SHAANXI UNIV OF SCI & TECH
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