Oral care solution containing lysozyme and plant extracts

A plant extract and oral care solution technology, applied in the application field of lysozyme, can solve the problems of inhibiting oral bacteria, the bacteriostatic effect is not obvious, and affecting the quality of food, etc., and achieves a good broad-spectrum bactericidal effect. The bactericidal ability of Lanseria-negative bacteria is weak, and the effect of making up for the weak bactericidal ability

Pending Publication Date: 2019-09-20
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial efficacy of most plant extracts is relatively low, and the antibacterial effect is not obvious when used in small doses. When used in large doses, there are problems that affect the quality of food, such as taste, color, smell, etc.
At present, there is no report on the compounding of lysozyme and plant extracts to inhibit oral bacteria

Method used

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  • Oral care solution containing lysozyme and plant extracts
  • Oral care solution containing lysozyme and plant extracts
  • Oral care solution containing lysozyme and plant extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A product containing lysozyme and plant extracts (Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea leaf extract, Glycyrrhiza glabra root extract, Chamomile flower extract, Rosemary leaf extract One or more) compound, according to the evaluation method of QB 2738-2012 antibacterial and bacteriostatic effect of daily chemical products, determine the effect of additive composition or monomer raw material on the common pathogenic bacteria Streptococcus mutans (G - ), Porphyromonas gingivalis (G - ), Staphylococcus aureus (G + ), Escherichia coli (G - ) inhibition.

[0042] 1. To study the antibacterial effect of monomer raw materials, the formula is any one of formulas 1 to 11 in Table 1.

[0043] Table 1 Composition and antibacterial effect of formulas 1 to 11

[0044]

[0045]

[0046] As can be seen from the results in Table 1, the inhibitory effect of lysozyme on Gram-positive bacteria is better than that ...

Embodiment 2

[0061] According to the results of Example 1, the compound of lysozyme + seven kinds of plant extracts was applied to the oral care solution.

[0062] An oral care solution containing an additive composition of lysozyme and plant extracts. The specific formulations of the oral care solution are shown in Table 5, formulations 33-39.

[0063] The preparation process is as follows:

[0064] Preparation of water-soluble components of group A: add humectants (polyethylene glycol, propylene glycol, glycerin), surfactants (sodium lauroyl sarcosinate, cocamidopropyl betaine), sweeteners (sodium saccharin , sucralose), water, stirring for 10-50min;

[0065] Preparation of group B oil-soluble components: Add solubilizer (PEG-40 hydrogenated castor oil, poloxamer 407), essence, ethanol, and stir for 10-50 minutes;

[0066] Component C is lysozyme and plant extract; add group A to group B and stir for 10-50 minutes; add components of component C to the AB mixture that has been fully mix...

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Abstract

The invention discloses an oral care solution containing lysozyme and plant extracts. The oral care solution comprises an additive composition composed of the lysozyme and the plant extracts, and the plant extracts refer to one or more of a herba centellae extract, a rhizoma polygoni cuspidati extract, a radix scutellariae extract, a tea leaf extract, a glycyrrhiza glabra extract, a chamomilla recutita flower extract and rosemary leaf extract. By compounding of the lysozyme and one or more of the plant extracts, on the one hand, problems of proneness to ecological disturbance of oral bacteria and drug resistance of the bacteria and failure in achieving an effect of oral disease prevention in frequent use of oral care products with chemical components are solved; on the other hand, the defect of a weak Gram-negative bacterium killing effect of the lysozyme is overcome while the defect of weak antibacterial efficacies in single use of the plant extracts is overcome as well, and great broad-spectrum bactericidal effects of the additive composition comprising the lysozyme and the plant extracts are achieved.

Description

technical field [0001] The invention relates to the technical field of lysozyme application, in particular to an oral care solution containing lysozyme and plant extracts. Background technique [0002] Oral problems are mainly caused by bacteria. Using effective toothpaste, mouthwash and treatment of oral diseases can significantly reduce the number of pathogenic bacteria in the oral cavity, improve or even eliminate oral diseases. Oral care products such as toothpaste and oral care liquid can achieve these functions mainly by the active ingredients or antibacterial ingredients in the products. These antibacterial ingredients are mostly chemical antibacterial agents (such as triclosan, cetylpyridinium chloride, Chlorhexidine, antibiotics, etc.), frequent use of oral care products containing these ingredients can easily cause oral microecological imbalance, or cause bacteria to develop drug resistance, which cannot prevent oral diseases, but instead leads to other oral diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/08A61P1/02A61P31/02A61P31/04
CPCA61K38/47C12Y302/01017A61K36/23A61K36/704A61K36/539A61K36/82A61K36/484A61K36/287A61K36/53A61K9/0056A61K9/08A61P1/02A61P31/04A61P31/02A61K2300/00
Inventor 徐天生褚夫江欧阳学琭
Owner HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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