Medicinal fatheadtree branchlet or bark new compound with function of promoting endothelial injury repair, preparation method of compound and application of compound

An endothelial injury and compound technology, which is applied in the field of compounds to achieve the effects of being convenient to take, promoting proliferation, and promoting endothelial injury repair

Active Publication Date: 2019-09-20
HAINAN SENQI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no report to isolate the bile woo...

Method used

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  • Medicinal fatheadtree branchlet or bark new compound with function of promoting endothelial injury repair, preparation method of compound and application of compound
  • Medicinal fatheadtree branchlet or bark new compound with function of promoting endothelial injury repair, preparation method of compound and application of compound
  • Medicinal fatheadtree branchlet or bark new compound with function of promoting endothelial injury repair, preparation method of compound and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. A new compound of bile wood that promotes cell repair, which is prepared by the following method:

[0036] (1) Take the stem of the gallwood, pulverize it, add water of 6 times the volume of the weight of the gallwood, soak and extract in 3 times, each time for 5 hours, combine the extracts, and concentrate to obtain the extract;

[0037] (2) Get the medicinal extract obtained in step (1), add dichloromethane and ethyl acetate of 3 times the volume of the medicinal extract weight to extract, extract respectively to obtain dichloromethane and ethyl acetate extraction parts; get the ethyl acetate part, Put on a silica gel chromatographic column, elute and separate with a dichloromethane-methanol elution solvent with a volume ratio of 95:5-85:15-70:30-50:50-10:90, and analyze and merge similar parts by TLC, Then use the preparative liquid phase to separate and elute with methanol at a volume concentration of 60% to obtain a new compound of choline (16-dehydroxymethylcho...

Embodiment 2

[0046] Take 16-dehydroxymethylcholigyn B and add purified water to dissolve it, add an appropriate amount of stevioside, adjust the pH to 5.5, subpackage, and sterilize to obtain the product.

Embodiment 3

[0048] Take 16-dehydroxymethylcholanine B, add dextrin and starch, mix evenly, granulate, and then pack into capsules to make capsules.

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PUM

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Abstract

The invention discloses a medicinal fatheadtree branchlet or bark alkaloid new compound with the function of promoting endothelial injury repair. The compound is prepared by a method including the steps: crushing medicinal fatheadtree branchlet or bark stems, adding water, performing soaking and extracting, collecting extraction liquid and performing vacuum concentration to obtain medicinal fatheadtree branchlet or bark extracts; extracting the extracts to obtain a dichloromethane portion and an ethyl acetate portion; feeding the ethyl acetate portion to a silica gel column; performing elution by taking dichloromethane-methanol with the volume ratio of 95:(5-10):90 as an elution solvent; combining similar portions by TLC (thin-layer chromatography) analysis; feeding a preparative liquid phase, taking methanol water as an eluent and performing liquid chromatography preparation to obtain the medicinal fatheadtree branchlet or bark new compound. Based on a cell repair related mechanism, under theoretical guidance, the proliferative activity of the medicinal fatheadtree branchlet or bark new compound is intensively studied, and experimental study indicates that the medicinal fatheadtree branchlet or bark new compound can obviously promote proliferation of HUVEC (human umbilical vein endothelial cell) cells and endothelial cell scratch repair and can be used for preparing a drug for controlling inflammatory endothelial injury.

Description

technical field [0001] The present invention relates to a compound isolated from the eucalyptus eucalyptus, in particular to a new compound of the eucalyptus eucalyptus which can promote the repair of endothelial damage. Background technique [0002] Nauclea officinalis Pierre ex Pitard. is a plant of Rubiaceae ebony, also known as ebony, bear bile tree, yellow bile wood, mountain bear bile, etc. It has the effects of clearing heat and detoxification, reducing swelling and pain, and is used to treat throat Inflammation, bronchitis, acute tonsillitis embolism. The alkaloids of bilewood have various pharmacological effects, including alleviating LPS-induced inflammation, antitumor activity, etc. [0003] Endothelial cell injury repair is an important link in the recovery of infectious diseases. Promoting endothelial cell proliferation can accelerate the repair of endothelial injury induced by various reasons, thereby promoting the healing of infectious diseases in the body. ...

Claims

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Application Information

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IPC IPC(8): C07D471/14A61P29/00A61P11/00A61P11/04A61P17/02A61K31/4375
CPCA61P11/00A61P11/04A61P17/02A61P29/00C07D471/14
Inventor 李永辉张俊清张旭光李海龙赖伟勇麦世瑛吴娇霞
Owner HAINAN SENQI PHARMA CO LTD
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