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Biologic cartilage tissue repair substitute material and preparation method thereof

A cartilage tissue and repair material technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of high acidity of degradation products, easy to cause inflammatory reactions, difficult product quality control, etc., to achieve strong practicability and high mechanical strength , the effect of simple operation

Inactive Publication Date: 2019-10-01
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, natural bio-scaffold materials have the advantages of good histocompatibility, being degradable by the human body and not causing inflammation, etc., but they lack certain mechanical strength, and the product quality is difficult to control. Although synthetic scaffold materials have good mechanical strength, However, its cell adsorption is poor, and its degradation products are highly acidic, which can easily cause inflammatory reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: provide a kind of biological cartilage tissue repair substitute material and preparation method thereof, comprise the steps:

[0015] Add 30g polyvinyl alcohol and 30g chitosan to 170g water, add 340g dimethyl sulfoxide to dissolve the above reaction reagents, dissolve at 95°C, then add 8g hydroxyapatite;

[0016] Then add 1g of UV photoinitiator, lower the temperature to 50°C and maintain this temperature, pass through nitrogen protection, adjust the pH to 7-8, stir at 850r / min for 1-2h, add 15g of cross-linking agent polyethylene glycol diacrylate Sonicate into the reaction reagent tube and dissolve.

[0017] Using 3D printing technology to print the above slurry to form a gel structure and the subchondral bone layer distributed in the gel structure, the active powder can be deposited at the bottom of the gel liquid.

[0018] 3D printing technology belongs to a kind of rapid prototyping technology. It is based on a digital model file, using powdered met...

Embodiment 2

[0019] Embodiment 2: 30g polyvinyl alcohol and 30g chitosan are added 170g water, add 340g dimethyl sulfoxide and dissolve above reaction reagent, 95 ℃ dissolve, then add 8g calcium carbonate;

[0020] Then add 2g of UV photoinitiator, lower the temperature to 40°C and maintain this temperature, pass through nitrogen protection, adjust the pH to 7-8, stir at a speed of 900 / min for 1-2h, add the cross-linking agent polyethylene glycol diglycidyl ether 15g was ultrasonically dispersed in the reaction reagent tube and dissolved.

[0021] Using 3D printing technology to print the above slurry to form a gel structure and the subchondral bone layer distributed in the gel structure, the active powder can be deposited at the bottom of the gel liquid.

Embodiment 3

[0022] Embodiment 3: 30g polyvinyl alcohol and 30g chitosan are added 170g water, add 340g dimethyl sulfoxide and dissolve above reaction reagent, dissolve at 95 ℃, add 8g silicon oxide again;

[0023] Then add 2g of UV photoinitiator, lower the temperature to 50°C and maintain this temperature, pass through nitrogen protection, adjust PH7-8, stir at 950 / min for 1-2h, add crosslinking agent N-methylolacrylamide 15g Sonicate into the reaction reagent tube and dissolve.

[0024] Using 3D printing technology to print the above slurry to form a gel structure and the subchondral bone layer distributed in the gel structure, the active powder can be deposited at the bottom of the gel liquid.

[0025] In order to highlight the technical effect of the present invention, the present invention also provides a comparison gel prepared without adding hydroxyapatite particles under the same conditions. Adopt tissue puncher to obtain cylinder (Φ 6mm, the composite gel material of thick 10mm)...

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Abstract

The invention provides a biologic cartilage tissue repair substitute material and a preparation method thereof. The material comprises a gel structural body and a sub-cartilage layer distributed on the gel structural body, the gel structural body is porous hydrogel of the mesh structure formed by polymerizing polyvinyl alcohol and chitosan, after an organic solvent is added into the hydrogel for dissolution, a cross linking agent is added for cross linking and curing to form the gel structural body, the sub-cartilage layer of the gel structural body forms a transition layer between connectivetissue and cartilage, and the sub-cartilage layer is composed of powder components with the osteogenic activity. According to the biologic cartilage tissue repair substitute material, the upper layergel structure has the mechanical performance close to cartilage, the sub-cartilage layer has the good tissue coherency, the mechanical strength is high, in addition, due to the proper stirring speed,large holes and high porosity can be formed conveniently, and the high porosity supplies space to cell regeneration.

Description

technical field [0001] The invention belongs to the field of imitation of cartilage biological materials, in particular to a biological cartilage tissue repair substitute material and a preparation method thereof. Background technique [0002] Cartilage damage is a relatively common disease in orthopedics. Trauma, osteochondritis, osteoarthritis, osteomalacia, etc. can all cause damage or defect of cartilage and subchondral bone. The incidence of bone and cartilage caused by trauma and social aging continues to increase, especially the lesions of articular cartilage increase significantly, so there are a large number of such patients worldwide. However, it is difficult to solve many fundamental problems such as tissue and organ defect repair by relying solely on traditional treatment modes. Bio-regenerated materials have the advantages of histocompatibility, mechanical compliance, good tissue induction, and no immune rejection, which can effectively relieve pain for patient...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/44A61L27/50A61L27/52A61L27/56
CPCA61L27/446A61L27/46A61L27/50A61L27/52A61L27/56A61L2430/06C08L29/04C08L5/08
Inventor 范让让
Owner WEST CHINA HOSPITAL SICHUAN UNIV