Preparation method of C-potassium isoascorbiate

The technology of isovitamin and ketone group is applied in the field of isovitamin C potassium production, which can solve the problems of difficult regeneration of ion exchange resin, difficulty in large-scale production and high production cost, and achieve the effects of simple method, improved conversion rate and improved purity.

Inactive Publication Date: 2019-10-01
新拓洋生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method directly uses ion exchange resins to purify 2-keto-gluconic acid fermentation broth. Macromolecules such as sugars and proteins are difficult to remove and ion exchange resins are not easy to regenerate. At the same time, the production cost is high, and it is currently only in the laboratory stage. , it is difficult to mass-produce

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of the different vitamin C potassium of the present embodiment may further comprise the steps:

[0026] 1) Pretreatment of 2-keto-gluconic acid fermentation broth: take 2-keto-gluconic acid fermentation broth and centrifuge with a centrifuge at a speed of 1000r / min. Concentrated sulfuric acid was added to the obtained supernatant to precipitate calcium ions, and then centrifuged and filtered at a speed of 600 r / min to remove calcium sulfate and obtain an acidified supernatant. The acidified supernatant is ultrafiltered with a hollow fiber ultrafiltration membrane, and the ultrafiltrate with a molecular weight cut-off of less than 50,000 is cut off. The ultrafiltrate was purified with a cation exchange resin to remove some cations and then concentrated. Concentration adopts vacuum distillation at a temperature of 50° C., and the solid content of the 2-keto-gluconic acid concentrate obtained by concentration is 80%.

[0027] 2) Esterification reac...

Embodiment 2

[0031] The preparation method of the different vitamin C potassium of the present embodiment may further comprise the steps:

[0032] 1) Pretreatment of 2-keto-gluconic acid fermentation broth: take 2-keto-gluconic acid fermentation broth and centrifuge with a centrifuge at a speed of 1000r / min. Concentrated sulfuric acid was added to the obtained supernatant to precipitate calcium ions, and then centrifuged and filtered at a speed of 600 r / min to remove calcium sulfate and obtain an acidified supernatant. The acidified supernatant is ultrafiltered with a hollow fiber ultrafiltration membrane, and the ultrafiltrate with a molecular weight cut-off of less than 50,000 is cut off. The ultrafiltrate was purified with a cation exchange resin to remove some cations and then concentrated. Concentration adopts vacuum distillation at a temperature of 55° C., and the solid content of the 2-keto-gluconic acid concentrate obtained by concentration is 80%.

[0033] 2) Esterification reac...

Embodiment 3

[0037] The preparation method of the different vitamin C potassium of the present embodiment may further comprise the steps:

[0038] 1) Pretreatment of 2-keto-gluconic acid fermentation broth: take 2-keto-gluconic acid fermentation broth and centrifuge with a centrifuge at a speed of 1000r / min. Concentrated sulfuric acid was added to the obtained supernatant to precipitate calcium ions, and then centrifuged and filtered at a speed of 600 r / min to remove calcium sulfate and obtain an acidified supernatant. The acidified supernatant is ultrafiltered with a hollow fiber ultrafiltration membrane, and the ultrafiltrate with a molecular weight cut-off of less than 50,000 is cut off. The ultrafiltrate was purified with a cation exchange resin to remove some cations and then concentrated. Concentration adopts vacuum distillation at a temperature of 50° C., and the solid content of the 2-keto-gluconic acid concentrate obtained by concentration is 85%.

[0039] 2) Esterification reac...

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Abstract

The invention relates to a preparation method of C-potassium isoascorbiate. The preparation method of the C-potassium isoascorbiate comprises the following steps that a 2-keto-gluconic acid fermentation solution is taken, centrifugation is carried out, concentrated sulfuric acid is added into supernatant, then filtration is carried out to obtain acidified clear liquid, the acidified clear liquid is subjected to ultrafiltration by using a hollow fiber ultrafiltration device, ultrafiltrate with the molecular weight less than 50,000 is intercepted, and concentration is carried out to obtain a 2-keto-gluconic acid concentrated solution; an alcohol solvent and a solid super acidic catalyst are added for an esterification reaction, then an alkaline potassium ion donor is added for a conversion reaction, and purification is carried out to obtain the C-potassium isoascorbiate. The 2-keto-gluconic acid fermentation solution is pretreated, so that the purity of the raw material of the esterification reaction is higher, the yield of 2-keto-gluconic acid ester is higher, and the subsequent esterification reaction efficiency of the 2-keto-gluconic acid ester and the yield of the C isoascorbiate converted from the 2-keto-gluconic acid ester are higher.

Description

technical field [0001] The invention belongs to the technical field of isovitamin C potassium production, and in particular relates to a preparation method of isovitamin C potassium. Background technique [0002] Isovitamin C potassium can be used in many fields instead of Isovitamin C sodium. For example, potassium isovitamin C can be used as a food additive in the food field, mainly for freshness preservation, color enhancement, anti-oxidation and antisepsis. The synthetic method of different vitamin C potassium is similar to the synthetic method of different vitamin C sodium. The synthesis method of potassium isovitamin C is as follows: using a catalyst to make 2-keto-gluconic acid lactonization, then adding an alkaline potassium ion donor, and purifying to obtain potassium isovitamin C after reaction. A part of mother liquor will be produced during the purification process, which contains a large amount of potassium ions, which can be converted into potassium fertilize...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/62C07H7/027C07H1/06
CPCC07D307/62C07H1/06C07H7/027
Inventor 崔凤霞高莉秦天苍曹琳青周俊俊张抗郭金权刘银霞曹晓伟龚舒史小利肖媛刘杉宋莹莹李永生
Owner 新拓洋生物工程有限公司
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