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A pt@pcn-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and its preparation method

A technology of dihydroartemisinic acid and photocatalyst, applied in organic compound/hydride/coordination complex catalyst, chemical instrument and method, physical/chemical process catalyst, etc., can solve the problem of high cost, high yield and conversion rate low problems, to achieve the effect of high porosity, lower production costs, and strong operability

Active Publication Date: 2022-04-22
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of metal nanoparticles, porphyrins and their derivatives as photocatalysts still has the problem of high cost or low yield and conversion.

Method used

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  • A pt@pcn-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and its preparation method
  • A pt@pcn-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and its preparation method
  • A pt@pcn-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 120mg Zr 6 Metal clusters are dissolved in 5ml of mixed solution A of N,N-dimethylacetamide and acetic acid, and the volume ratio of N,N-dimethylacetamide and acetic acid in solution A is any one of 0:5 to 4:1. 60 mg of phenylporphyrin tetracarboxylate was dissolved in 2.5 ml of N,N-dimethylacetamide to obtain mixed solution B. Pt nanoparticles (1 mg, 3 mg, 5 mg) were dissolved in N, N-dimethylacetamide with a volume of 2.5 ml to obtain a mixed solution C. The three are completely mixed under the stirring condition that the rotating speed of the magnet is 900 rpm, stirring is carried out at 25 degrees Celsius, and the stirring time is controlled between 0.5-24 hours. The preliminary products were collected by centrifugation, washed three times with N, N-dimethylacetamide, washed once with acetone, and dried to obtain pure phases of Pt@PCN-224-1, Pt@PCN-224-3, and Pt@PCN-224-5, respectively. for the final product.

Embodiment 2

[0035] 120mg Zr 6 Metal clusters were dissolved in 5ml of mixed solution A of N,N-dimethylacetamide and acetic acid, and the volume ratio of N,N-dimethylacetamide and acetic acid in solution A was 2:3. Dissolve 60mg of TCPP-Zn (or TCPP-Co, TCPP-Ni) in 2.5ml of N, N-dimethylacetamide to obtain mixed solution B. 1 mg of Pt nanoparticles was dissolved in 2.5 ml of N,N-dimethylacetamide to obtain a mixed solution C. The three are completely mixed under the stirring condition that the rotating speed of the magnet is 900 rpm, and the stirring is carried out at 25 degrees Celsius for 9 hours. The preliminary products were collected by centrifugation, washed three times with N, N-dimethylacetamide, washed once with acetone, and dried to obtain pure phases of Pt@PCN-224-Zn, Pt@PCN-224-Co, and Pt@PCN-224-Ni respectively. for the final product.

Embodiment 3

[0037] Dihydroartemisinic acid (25 mg, 0.106 mmol), Pt@PCN-224 obtained in Example 1 and Example 2 or its derivatives (0.002 mmol, based on porphyrin), trifluoroacetic acid (8 μL), dispersed in 5 ml di A mixed solution was obtained in methyl chloride. The mixed solution was slowly bubbled with oxygen for 3 hours under LED lighting conditions. Remove the dichloromethane contained in the reactant, by1 H NMR further proved the conversion rate of dihydroartemisinic acid. Finally, the conversion rate of Pt@PCN-224-1 was 98%, and the yield rate was 45%. The conversion of Pt@PCN-224-3 was 99%, and the yield was 50%. The standardization rate of Pt@PCN-224-5 was 99%, and the yield rate was 51%. The conversion rate of Pt@PCN-224-Zn is 99%, the yield rate is 54%, the conversion rate of Pt@PCN-224-Co is 99%, the yield rate is 53%, and the conversion rate of Pt@PCN-224-Ni is 99%. , and the yield was 52%.

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Abstract

Pt@PCN‑224 and its derivatives are used as photocatalysts for the preparation of artemisinin from dihydroartemisinic acid, and its preparation method is provided, which belongs to the field of metal organic framework materials preparation and application; using MOFs with large specific surface area and high porosity The advantages of using it as a carrier, and synergistically using porphyrin and Pt nanoparticles as a photocatalyst, the interaction ensures the high activity and high selectivity of the catalyst, which is conducive to improving its catalytic effect; using biosynthetic precursors (artemisia annua acid) for photochemical semi-synthesis, thereby reducing the cost of artemisinin extraction or total synthesis; the preparation method of Pt@PCN‑224 photocatalyst for the preparation of artemisinin from dihydroartemisinic acid is simple and operable.

Description

technical field [0001] The invention belongs to the field of metal-organic framework material preparation and application thereof, and in particular relates to a Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and a preparation method thereof. Background technique [0002] Metal Organic Frameworks, or MOFs for short, is a porous material with a periodic network structure formed by the bonding of metal ions or metal clusters and organic ligands through coordination bonds. It has the advantages of high porosity, large specific surface area, designable and adjustable skeleton structure, etc. Based on the above advantages, MOFs have gradually been valued by researchers. In the past ten years, MOFs have shown great application prospects in fluorescence, catalysis, gas adsorption and separation, proton conductors, and drug delivery. [0003] Malaria is a serious worldwide epidemic, and more than 300 million people are infected with malaria every ye...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/28C07D493/20
CPCB01J31/28C07D493/20B01J2531/48B01J2531/26B01J2531/845B01J2531/847B01J2531/025B01J2231/766B01J35/393B01J35/23B01J35/39
Inventor 张亮亮刘振国陈妍慧李佳佩
Owner NORTHWESTERN POLYTECHNICAL UNIV
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