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Injection containing amino acid and sodium hyaluronate and preparation method of injection

A technology of sodium hyaluronate and amino acid, applied in the fields of medical beauty and biomedicine, can solve the problems of poor stability of amino acid, easy degradation, and insignificant filling effect, and achieve the effect of no crystal precipitation, promotion of protein synthesis, and good clarity.

Inactive Publication Date: 2019-10-18
王月玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The concentration of sodium hyaluronate in the compound solution is 1.000-5.000mg / mL, the concentration of amino acid is 0.100-0.500mg / mL, the concentration is relatively thin, and the filling effect is not obvious
And in the solution state, the amino acid has poor stability and is easy to degrade

Method used

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  • Injection containing amino acid and sodium hyaluronate and preparation method of injection
  • Injection containing amino acid and sodium hyaluronate and preparation method of injection
  • Injection containing amino acid and sodium hyaluronate and preparation method of injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Preparation of amino acid freeze-dried powder: Accurately weigh 4.0g of glycine, 1.2g of L-proline, 5.0g of L-leucine, and 4.5g of L-lysine, add 3000ml of water for injection to dissolve completely, and then add manna 9.0g of alcohol and 3.5g of dextran, stir evenly, adjust the pH of the solution to 6.5 with sodium hydroxide solution or hydrochloric acid solution, add 3g of activated carbon to filter, use a 0.22μm microporous membrane to filter the filtrate, and put the fine filtrate into a vial , 3ml per bottle, freeze-dried in a freezer to obtain freeze-dried amino acid powder.

[0039] 2) Preparation of sodium hyaluronate solution: Accurately weigh 50.0 g of sodium hyaluronate, add 1000 ml of phosphate buffer solution with a pH of 6.5 to dissolve, adjust the pH of the solution to 6.5 with 1 mol / L sodium hydroxide solution, stir well, and use 0.22 μm Filter through a microporous membrane to obtain a sodium hyaluronate solution.

Embodiment 2

[0041] 1) Preparation of amino acid freeze-dried powder: Accurately weigh 8.6g of glycine, 2.6g of L-proline, 10.0g of L-leucine, and 8.8g of L-lysine, add 3000ml of water for injection to dissolve completely, and then add manna 17.9g of alcohol and 7.2g of dextran, stir evenly, adjust the pH of the solution to 7.0 with sodium hydroxide solution or hydrochloric acid solution, add 6g of activated carbon to filter, use a 0.22μm microporous membrane to filter the filtrate, and put the fine filtrate into a vial , 3ml per bottle, freeze-dried in a freezer to obtain freeze-dried amino acid powder.

[0042] 2) Preparation of sodium hyaluronate solution: Accurately weigh 100.0 g of sodium hyaluronate, add 1000 ml of pH 7.0 phosphate buffer solution to dissolve, adjust the pH of the solution to 7.0 with 1mol / L sodium hydroxide solution, stir well, and use 0.22 μm Filter through a microporous membrane to obtain a sodium hyaluronate solution.

Embodiment 3

[0044] 1) Preparation of amino acid freeze-dried powder: Accurately weigh 14.0g of glycine, 4.5g of L-proline, 16.0g of L-leucine, and 14.0g of L-lysine, add 3000ml of water for injection to completely dissolve, and then add manna 28.5g of alcohol and 11.5g of dextran, stir evenly, adjust the pH of the solution to 5.5 with sodium hydroxide solution or hydrochloric acid solution, add 3g of activated carbon to filter, filter the filtrate with a 0.22μm microporous membrane, and put the fine filtrate into a vial , 3ml per bottle, freeze-dried in a freezer to obtain freeze-dried amino acid powder.

[0045] 2) Preparation of sodium hyaluronate injection: Accurately weigh 115.0 g of sodium hyaluronate, add 1000 ml of pH 5.5 phosphate buffer solution to dissolve, adjust the pH of the solution to 5.5 with 1 mol / L hydrochloric acid solution, stir well, and dissolve with 0.22 μm Pore ​​membrane filtration to obtain sodium hyaluronate injection.

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Abstract

The invention relates to an injection containing amino acid and sodium hyaluronate and a preparation method of the injection, and belongs to the technical field of medical beautifying and biomedicine.The injection containing the amino acid and sodium hyaluronate is mainly prepared from, by weight, 1.7-17.2 parts of glycine, 0.5-5.2 parts of L-proline, 2.0-20.0 parts of L-leucine, 1.8-17.6 parts of L-lysine, 20.0-200.0 parts of sodium hyaluronate, 3.6-35.8 parts of an excipient, 1.4-14.3 parts of a stabilizer and 1,000 parts of injection water. The injection containing the amino acid and sodium hyaluronate is prepared by means of the method and can achieve quick filling, remove wrinkles, striae gravidarum and other flaws on the skin, promote the growth of new skin cells and promote the youthfulness of the facial state and has an anti-aging function.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and specifically relates to an amino acid-containing sodium hyaluronate injection and a preparation method thereof. Background technique [0002] It has become a common phenomenon to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology, so as to maintain the perfect and youthful facial shape. Among various plastic surgery techniques, injection beauty technology accounts for the largest proportion, accounting for about 40% of the entire beauty market. Injection beauty technology is a beauty technology that partially modifies the human body through injection to achieve exquisite local shape and harmonious overall shape. This technology has the characteristics of zero recovery, quick effect and high safety, and is the first choice for beauty needs. [0003] Injection cosmetology is a kind of non-surgical plastic cosmetology....

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/54A61L27/58
CPCA61L27/54A61L27/20A61L27/58A61L2400/06A61L2300/214A61L2300/40A61L2300/604A61L2300/236
Inventor 王月玲
Owner 王月玲
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