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Method for extracting original solution of bear gall powder eye drops

An extraction method and technology of bear bile powder, which is applied in the field of extraction of bear bile powder eye drops stock solution, can solve problems such as large randomness, substandard washing technology, and low product purity, and achieve the effect of ensuring content and activity

Pending Publication Date: 2019-10-22
CHANGCHUN CHANGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The removal of supersaturated lipid protein in the process should be the key purpose of the preparation. At present, the preparation parameters for degreasing and purification in the existing process are relatively random. Large-scale production is used for product purity is not high

Method used

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  • Method for extracting original solution of bear gall powder eye drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of extracting method of bear bile powder eye drop stoste, comprises following processing steps:

[0024] (1) Grind 28 g of the weighed bear bile powder raw material into 100 mesh powder.

[0025] The raw material of bear bile powder is in the form of crystalline flakes, similar to a polymer structure, and has strong adsorption properties. It absorbs and dehydrates with water to reduce the effect of water dissolution. Therefore, grinding it into powder can increase the contact area with water molecules and achieve complete dissolution. .

[0026] (2) Take another 140ml of water for injection at 45°C and add 28g of bear bile powder while stirring until completely dissolved, thereby preparing an aqueous solution of bear bile powder.

[0027] Bear bile powder contains 90% fibrinogen and 67.31% mucin, most of which are lipid substances. Reasonable temperature control is the key technology for the extraction process of removing supersaturated lipoproteins in bear bile...

Embodiment 2

[0038] In the method of this embodiment, in step (2), the temperature of the water solution for preparing bear bile powder is 23°C, the temperature of the extract before the alcohol precipitation in step (3) is 4°C, and the resting temperature of the alcohol precipitation solution is 4°C, The resting time of the alcohol precipitation solution was 48h, and the rest were the same as in Example 1.

Embodiment 3

[0040] In the method of this embodiment, in step (2), the temperature of the aqueous solution of bear bile powder is 45°C, the temperature of the extract before the alcohol precipitation in step (3) is 18°C, and the resting temperature of the alcohol precipitation is 5°C. The resting time of the alcohol precipitation solution was 48h, and the rest were the same as in Example 1.

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PUM

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Abstract

The invention discloses a method for extracting an original solution of bear gall powder eye drops, wherein the method includes the following process steps: (1) taking 1 part by weight of bear gall powder, and grinding the bear gall powder into powder; (2) preparing an aqueous solution of the bear gall powder; (3) selecting specific mixing temperature and alcohol precipitation temperature in the alcohol precipitation step of the bear gall powder; (4) washing a precipitate; and (5) merging the supernatant. The method can largely remove invalid components such as lipid protein and ensure the content and activity of taurochordoxycholic acid which is the main medicine component in the extract liquid.

Description

technical field [0001] The invention relates to the field of molecular biological separation, in particular to a method for extracting the stock solution of bear bile powder eye drops. Background technique [0002] Bear bile powder is a dry powder of bile drained from black bears, and its main chemical components include bile acid-binding tauroursodeoxycholic acid, chenodeoxycholic acid, cholic acid, deoxycholic acid, trace amounts of bile pigment and non-bile acids Composition protein, peptide, trace free amino acid, cholesterol, fatty acid and inorganic element. [0003] Tauroursodeoxycholic acid (TUDCA) is a conjugated bile acid formed by shrinking the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine. Tauroursodeoxycholic acid is an effective component of bear bile, and the bile acid composition has strong antipyretic, antibacterial, analgesic and antispasmodic effects, and has strong inhibitory effect on Gram-positive bacteria. The removal o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K9/08A61P27/02A61P31/04
CPCA61K35/413A61K9/08A61K9/0048A61P27/02A61P31/04
Inventor 王宝成
Owner CHANGCHUN CHANGQING PHARM GRP CO LTD