Preparation method of selenium carrageenan

A technology of selenized carrageenan and carrageenan, which is applied in the preparation of selenized carrageenan and the field of preparation of selenized polysaccharide compounds, can solve the problems of incomplete separation of organic substances and inorganic substances, low selenium content of selenized carrageenan, The quality of the final product is not high, and the effect of excellent powder properties, uniform powder particle size, and hygienic production process is achieved.

Pending Publication Date: 2019-10-22
QINGDAO PENGYANG BIOLOGICAL ENG
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Problems solved by technology

The selenized carrageenan prepared by the above two methods has a low selenium content, and at the same time, too many other elements and groups have been introduced in the preparation process, which may contain harmful elements in the obtained product. Finally, the separation and purification process adopts ethanol fractional precipitation, The method of drying and refining treatment leads to incomplete separation of organic substances and inorganic substances, resulting in low quality of final products
[0006] In addition, it is also mentioned in the literature that selenized carrageenan oligosaccharides are obtained by dialysis with a dialysis bag with a molecular weight cut-off of 500, but the retention rate is low, and the selenium content of the prepared selenized carrageenan is low, and if there are undegraded excessive Large molecular weight selenized carrageenan fragments will affect the application of later products, such as being difficult to dissolve and absorb in clinical use

Method used

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  • Preparation method of selenium carrageenan

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Effect test

Embodiment 1

[0034] (1) Degradation of carrageenan: Make 1.0kg of carrageenan (Shanghai Beilian Biotechnology Co., Ltd., white uniform powder) into a solution with a mass concentration of 0.5% with deionized water, and then add 5M acetic acid solution to adjust the pH value of the solution to 4.0 , to make the solution acidic, and use an ultrasonic wave with a power of 300W to carry out the degradation reaction for 7 hours under the adjustment of an ice bath at 2°C;

[0035] (2) Selenization reaction: add 0.16kg sodium selenite and 0.32kg BaCl to the carrageenan sol 2 , heated to 30°C and reacted for 14 hours to generate selenized carrageenan; after the reaction was completed, the reaction solution was lowered to room temperature;

[0036] (3) Remove barium ions: add 0.25 kg of anhydrous sodium sulfate to the reaction solution cooled to room temperature in step (2), so that the barium ions in the reaction solution are formed as precipitates; centrifuge the reaction solution to remove the b...

Embodiment 2

[0041] (1) Degradation of carrageenan: After making 1.5kg of carrageenan (Shanghai Beilian Biotechnology Co., Ltd., white uniform powder) into a solution with a mass concentration of 2% with deionized water, add 5M acetic acid solution to adjust the pH value of the solution to 3.0 , to make the solution acidic, and use an ultrasonic wave with a power of 500W to carry out the degradation reaction for 5 hours under the adjustment of an ice bath at 5°C;

[0042] (2) Selenization reaction: add 0.68kg sodium selenite and 1.5kg BaCl to the carrageenan sol 2 , heated to 50°C and reacted for 10 hours to generate selenized carrageenan; after the reaction was completed, the reaction solution was lowered to room temperature;

[0043] (3) Remove barium ions: add 1.25 kg of anhydrous sodium sulfate to the reaction solution cooled to room temperature in step (2), so that the barium ions in the reaction solution are generated as precipitates; the reaction solution is centrifuged to remove th...

Embodiment 3

[0048] (1) Degradation of carrageenan: After making 1.8kg of carrageenan (Shanghai Beilian Biotechnology Co., Ltd., white uniform powder) into a solution with a mass concentration of 2.5% with deionized water, add 3M acetic acid solution to adjust the pH value of the solution to 3.5 , to make the solution acidic, and use an ultrasonic wave with a power of 600W to carry out the degradation reaction for 4.5h under the adjustment of an ice bath at 3°C;

[0049] (2) Selenization reaction: add 0.8kg sodium selenite and 1.75kg BaCl to the carrageenan sol 2 , heated to 70°C and reacted for 7 hours to generate selenized carrageenan; after the reaction was completed, the reaction solution was lowered to room temperature;

[0050] (3) Remove barium ions: add 1.56 kg of anhydrous sodium sulfate to the reaction solution cooled to room temperature in step (2), so that the barium ions in the reaction solution are generated as a precipitate; the reaction solution is centrifuged to remove the...

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Abstract

The invention discloses a preparation method of selenium carrageenan. The preparation method comprises the following steps that carrageenan is degraded by ultrasonic under the condition of acidic ice-water bath, and is reacted with seleninic acid or selenite under catalysis of barium ions or calcium ions, sodium sulfate sediment is added to remove the barium ions or the calcium ions, separation isachieved through a separation membrane after neutralizing, and finally maltodextrin spray drying is added to prepare selenium carrageenan powder. According to the preparation method, the carrageenanis degraded by the ultrasonic, more rapidness, mildness and environment-friendly are achieved; organic macromolecule selenium carrageenan is separated from micromolecule selenium carrageenan and otherinorganic substances more efficient and environmental-friendly throughseparation membrane filtration; and according to using of the spray drying, the particle size is more uniform, the production link is more sanitary, and the product purity is high.

Description

technical field [0001] The invention relates to a preparation method of selenized polysaccharide compounds, in particular to a preparation method of selenized carrageenan, and belongs to the technical field of preparation and separation of marine polysaccharide compounds. Background technique [0002] Selenium is one of the essential micronutrients for humans and animals. It has various biological activities such as scavenging free radicals, anti-oxidation (50-500 times that of vitamin E), inhibiting the production of lipid peroxide, and enhancing immune function. According to statistics, there are more than 40 countries and regions lacking selenium in the world, and China is the region with the most serious selenium deficiency in the world. The provinces with selenium deficiency account for about 72% of the total area of ​​the country, and 30% of them are severely selenium deficient areas. In parts of 22 provinces and cities in China, about 700 million people live in low-se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A23L33/16
CPCA23V2002/00A23L33/16C08B37/0042A23V2200/30
Inventor 车勇张银萍杨迎
Owner QINGDAO PENGYANG BIOLOGICAL ENG
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