Application of palladium complex to fatty amine formylation reaction

The technology of fatty amine formyl and fatty amine formamide is applied in the application field of palladium complexes in fatty amine formylation reaction, and can solve the problems of mild reaction conditions, small adaptability of substrates, use of toxic reagents, and the like, Achieve the effect of easy separation, cheap and low toxicity separation, and high yield
CN110368989AActive Publication Date: 2019-10-25SHANGHAI INST OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF TECH
Publication Date
2019-10-25

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Abstract

The invention relates to application of a palladium complex to a fatty amine formylation reaction. A N,N-coordinated palladium complex containing a meta-carbobane ligand is used as a catalyst, N,N-dimethyl formamide is used as a formylating reagent and a solvent to catalyze the fatty amine formylation reaction to prepare a fatty amine carboxamide compound. Compared with the prior art, the N,N-coordinated divalent palladium complex containing the metacarbanyl ligand in the application is high in catalytic activity under mild conditions and can catalyze the formylation reaction of a fatty amine.DMF is further used as a formylating reagent and a solvent, and is inexpensive, low in toxicity, easy to separate and high in yield (88-96%).
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Description

technical field

[0001] The invention belongs to the technical field of synthetic chemistry and relates to the application of a palladium complex in fatty carbamylation reaction. Background technique

[0002] Formamide widely exists in natural products and is often used as a pharmacodynamic functional group of drugs, and most of its derivatives have significant biological activity. In organic synthesis reactions, formyl is one of the most effective protecting groups for amino groups in amine compounds, and the formed formamide is also an important precursor for the synthesis of isocyanates and formamidines. In addition, formamide can also be used as a Lewis base catalyst to catalyze alkylation and hydrosilylation reactions. As early as the 1950s, Fieser et al. successfully used formic acid as a raw material to realize the formylation of aniline. Subsequently, various formylating reagents were reported correspondingly, such as chloral, ammonium formate, formate ester, etc. ...

Claims

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