A preparation method of pentafluorouracil/mesoporous silicon dioxide/oxidized pullulan drug sustained release system with pH response
A technology of mesoporous silica and pullulan, which is applied in the field of biomedicine, can solve the problems of premature drug release and burst release, and achieve the effects of good biocompatibility, simple preparation, and good film-forming properties
Active Publication Date: 2022-06-28
CHANGZHOU UNIV
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Problems solved by technology
Although mesoporous silica has been used in the field of drug sustained release, there are still some shortcomings, such as premature drug release or burst release, so we choose pullulan to improve the above shortcomings
Method used
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Embodiment 1
[0026] A preparation method of a pH-responsive pentafluorouracil / mesoporous silica / oxidized pullulan drug sustained-release system, comprising the following steps:
[0027] (1) Weigh 1.0g of pullulan and dissolve it in deionized water, add 0.43g of sodium periodate, stir the solution continuously for 24h under dark conditions, then add 1.0mL of ethylene glycol and stir for 1h. The product was placed in a dialysis bag with a molecular cut-off of 3500, put into deionized water for purification for 3 days, and then freeze-dried at -45°C for 24 hours to obtain oxidized pullulan;
[0028] (2) Weigh 0.5 g of cetyltrimethylammonium bromide, add it to a mixed solution of 1.4 mL of ammonia water, 90 mL of deionized water and 70 mL of ethanol, stir the mixed solution mechanically for 30 minutes, then add 0.8 mL of positive Ethyl silicate and 0.4 mL of 3-aminopropyltriethoxysilane were successively added dropwise to the continuously stirred solution, reacted for 6 hours, the sample was c...
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Abstract
The invention relates to a preparation method of a pentafluorouracil / mesoporous silicon dioxide / oxidized pullulan drug sustained release system with pH response. The method comprises the following steps: preparing oxidized pullulan polysaccharide, preparing aminated mesoporous silica, preparing pentafluorouracil / aminated mesoporous silica, preparing pentafluorouracil / mesoporous silica / oxidized pullulan drug Sustained release system. The beneficial effects of the present invention are: aminated mesoporous silica and oxidized pullulan polysaccharide are prone to Schiff base reaction, and pullulan polysaccharide has good film-forming properties, so it can be used for aminated aminated polysaccharides loaded with drugs. Mesoporous silica is coated to block its pores. Since the generated acylhydrazone bonds are sensitive to pH, the drug can be released in a controlled manner through pH stimulation. The drug sustained-release system is simple to prepare, has good biocompatibility, and can be widely used in the field of biomedicine.
Description
technical field [0001] The invention relates to a preparation method of a pH-responsive pentafluorouracil / mesoporous silica / oxidized pullulan polysaccharide drug sustained-release system, belonging to the field of biomedicine. [0002] technical background [0003] In the process of exploring the construction of drug sustained-release systems with nanocarriers as the main material, mesoporous silica is often It is used to construct stimuli-responsive drug controlled release systems. Although mesoporous silica has been used in the field of drug sustained release, there are also some disadvantages, such as premature drug release or burst release, so we choose pullulan to improve the above shortcomings. Pullulan is a neutral, biodegradable, non-toxic, non-immunogenic non-ionic polysaccharide. Due to its good film-forming properties and easy modification characteristics, pullulan is and its derivatives can be used in drug release system. [0004] The first step of the present ...
Claims
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IPC IPC(8): A61K9/70A61K47/04A61K47/36A61K31/513A61P35/00
CPCA61K9/7007A61K47/02A61K47/36A61K31/513A61P35/00
Inventor 孔泳李尚基吴大同秦勇陶永新
Owner CHANGZHOU UNIV