A magnetic magnesium-loaded artificial bone and a method for preparing a magnetic magnesium-loaded artificial bone using 3D printing

Abstract

The invention discloses a magnetic magnesium-loaded artificial bone and a method for preparing the magnetic magnesium-loaded artificial bone by 3D printing. The artificial bone includes the following components in parts by weight: PLA 6-10, β‑TCP 0.8-1.2, MgSO 4 0.3~0.7, Fe 3 o 4 0.3~0.7. The method uses computer-aided design software to carry out bionic design on the model of the bone scaffold, and then according to the principle of component bionics, PLA, β-TCP, MgSO 4 , Fe 3 o 4 The four raw materials were mixed according to the ratio of 8:1:0.5:0.5, and the obtained powder was centrifuged, washed, dried, and ground to obtain a composite powder. The obtained composite powder was sintered with a 3D printer to prepare a magnetic magnesium-loaded artificial bone.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical orthopedic materials, and in particular relates to a magnetic magnesium-loaded artificial bone and a method for preparing the magnetic magnesium-loaded artificial bone by 3D printing. Background technique [0002] There are about 15 million patients with bone tissue defects caused by trauma, infection, and tumors in my country every year, and effective bone defect repair is urgently needed. The clinical methods for bone tissue defect repair mainly include mechanical reconstruction and biological reconstruction. The commonly used materials for mechanical reconstruction are mainly artificial metal prosthesis, which has significant disadvantages compared with biological materials: ①Metal prosthesis repairing bone tissue defect is a This mechanical reconstruction method has a limited service life and needs repeated revisions in the long run; ②The metal prosthesis has high mechanical ...

AI Technical Summary

Problems solved by technology

Artificial bones made of these materials can only meet some of the performance requirements of ideal artificial bone materials: ①Bioceramic artificial bones made of inorganic materials have good biocompatibility, but poor mechanical properties, hard and brittle, and easy to break. Moreover, it lacks osteoinductive properties; ②Although bioactive artificial bones made of organic materials have certain osteoinductive properties, their biomechanical properties are poor and cannot match the mechanical properties of human bone tissue; ③Composite materials are both inorganic The advantages of materials and organic materials can have both osteoconduction and a certain degree of osteoinductive properties, but the single preparation method cannot meet the individual needs of different bone tissue defects, and cannot achieve long-term effective osteoinductive effects

In addition, since human bone tissue is composed of organic matter and inorganic salts, the ratio is about 1:2, and there are significant differences in the structure of cancellous bone and cortical bone, and the current preparation methods of artificial bone materials are still unable to achieve bone tissue structure. Personalized requirements on the above and component composition, and it is impossible to endow artificial bone materials with long-term osteoinductive properties