Isoquinoline-based ratio-dependent detecting probe for fluoride ions and preparation method and application of isoquinoline-based ratio-dependent detecting probe

Abstract

The invention discloses an isoquinoline-based ratio-dependent detecting probe for fluoride ions and a preparation method and application of the isoquinoline-based ratio-dependent detecting probe. Thefluorescent probe has a structure as shown in a formula I, o-alkynyl aldehyde is adopted as a raw material of the probe, and a reaction is performed between the raw material and a benzylamine derivative so as to obtain the probe. The probe has stable optical performance, high detection sensitivity to fluoride ions, a lower limit of detection, a detection limit of 3.79 nM and a response range of 0.2-10 [mu]M; good selectivity is achieved, no responses to chloride ions, bromide ions, iodate ions, periodate ions, nitrate ions, nitrite ions, acetate ions, carbonate ions, sulfate ions, sulfite ionsand other negative ions are generated; and synthesis is simple, the conditions are mild, and the yield is high. The fluorescent molecular probe has practical application values in biochemistry and environmental chemistry and other fields, especially detection of fluoride ions in water.

Description

technical field

[0001] The invention relates to the technical field of chemical analysis and detection, in particular to a ratiometric fluoride ion detection probe based on isoquinoline and its preparation method and application. Background technique

[0002] Anions are important elements to maintain biological life activities, and the design and synthesis of new anion fluorescent detection probes is an important research field in the discipline of chemical analysis. Fluoride ion is considered as a trace element necessary for the growth of teeth and human body, it can protect teeth and prevent osteoporosis. Both excess and deficiency may lead to certain diseases. Excessive intake of fluorine-containing compounds can cause serious diseases, such as fluorosis, urinary stones, tumors, organ lesions, and skeletal fluorosis. The United States Environmental Protection Agency requires that the maximum fluoride ion concentration in healthy drinking water is 4ppm (211μM). Therefore,...

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