A kind of method for synthesizing azithromycin
A technology for azithromycin and erythromycin oxime, which is applied in the field of synthesizing azithromycin, can solve the problems of low yield, high requirements for hydrogenation reaction personnel operation and equipment conditions, etc., and achieves the effects of improving purity, shortening acidification and holding time, and reducing damage
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[0027] Add 44 grams of erythromycin oxime, add 300 grams of water, add 15 grams of methanesulfonyl chloride dropwise under 5 degrees, control the pH to 3-4 during the dropping process (PH is too low, add baking soda), and add 30 grams of Dichloromethane was extracted once, and the aqueous layer was added dropwise with 85 g of 7% potassium borohydride aqueous solution (prepared and used now) in four drops, each time for 10 minutes. After dripping and keeping warm for 1.5 hours to pass, add 300 grams of dichloromethane, adjust the pH to 9, separate layers, extract the water layer with 20 grams of dichloromethane once, combine the organic layer, wash the organic layer until the pH reaches 8, add 3% sorbic acid 300 grams of sugar alcohol aqueous solution, reduce to 5 degrees, drop 6% dilute hydrochloric acid within 5 minutes to adjust the pH to 1, keep warm for 3 minutes, add 20% liquid alkali dropwise within 5 minutes to adjust the pH to 10, separate layers, and wash the organic l...
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