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Polyphenols/peg based hydrogel system for dental varnish

A hydrogel and system technology, applied in the direction of dental prosthesis, dentistry, dental preparations, etc.

Inactive Publication Date: 2019-11-26
DENTSPLY SIRONA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] As noted above, there is a continuing need for paint systems that overcome the problems of existing paint systems

Method used

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  • Polyphenols/peg based hydrogel system for dental varnish
  • Polyphenols/peg based hydrogel system for dental varnish
  • Polyphenols/peg based hydrogel system for dental varnish

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0015] According to one embodiment of the present disclosure, the hydrogel system is capable of forming a crosslinked film while adhering to the enamel surface.

[0016] A second aspect of the present disclosure herein is a dental varnish composition comprising a hydrogel system and at least one fluoride source, wherein the hydrogel system comprises (a) at least one fluoride having at least one phenolic group (b) at least one polymer comprising a functional group capable of forming hydrogen bonds with said polyphenol; and (c) a metal ion. The dental varnish is water soluble.

[0017] According to an embodiment of a dental lacquer composition, said at least one polyphenol is selected from the group consisting of resveratrol, tannic acid, gallic acid, isoflavones, flavonols, flavones, dihydroisoflavones, dihydroflavones, hydroxycinnamon Acids, tocopherols, anthocyanins, proanthocyanidins, catechins, and combinations thereof.

[0018] According to another embodiment of the dent...

Embodiment

[0135] 1. Synthesis of TA / GA / PEG / Metal based paint formulations:

[0136] First, a solution containing tannic acid and gallic acid (TA / GA solution) was prepared. Tannic acid (0-3.00 g) and gallic acid (0-7.00 g) were weighed and dissolved in about 15 ml of ethanol. After complete dissolution, about 35 mL of deionized water and (0-600 mg) aluminum chloride (metal trivalent ion) and (0-500 mg) boric acid were added to the solution. In a separate vessel, polyethylene glycol (PEG) (1000-10000 Da MWCO) was prepared in deionized water by dissolving approximately 3.00 g of PEG in approximately 50 mL of deionized water. The TA / GA solution and PEG solution were then mixed thoroughly, and the solvent was removed by centrifugation at about 2000 rpm for about 5 min to collect the hydrogel system. The final color and adhesive properties depend on the relative ratio of gallic acid / tannic acid / PEG / aluminum chloride, pH, terminal functional groups of PEG, number of PEG arms.

[0137] TA-...

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PUM

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Abstract

Described herein are dental treatment compositions, more particularly, a dental varnish composition useful in effective fluoridation, enhancement of remineralization the tooth enamel, and hypersensitivity through occlusion of dentine tubule. The dental varnish composition includes a hydrogel system and at least one fluoride source, wherein the dental varnish is water soluble. The hydrogel system includes at least one polyphenol having at least one phenol group, at least one polymer, and a metal ion. Described herein are also methods of making such dental varnish composition.

Description

technical field [0001] The present disclosure relates generally to a dental treatment composition, and more particularly to a dental varnish composition, useful in effective fluoridation, enhanced remineralization of tooth enamel, and hypersensitivity by sealing dentinal tubules . The dental varnish composition includes a hydrogel system and at least one fluoride source, wherein the dental varnish is water soluble. The hydrogel system comprises at least one polyphenol having at least one phenolic group, at least one polymer and metal ions. The present disclosure also provides methods of making such dental varnish compositions. [0002] Background of the invention [0003] Caries and hypersensitivity are two very common dental conditions. Dental varnishes such as fluoride are known to be able to treat both caries and hypersensitivity. Fluoride forms CaF on teeth 2 protective layer. As a result, the dissolution of enamel (which is mainly composed of hydroxyapatite) under ...

Claims

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Application Information

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IPC IPC(8): A61K6/00A61K6/891
CPCA61K6/831A61K6/84A61K6/891A61K6/20C08L33/08C08L33/10C08L33/12C08L33/14C08L39/06C08L29/04C08L5/00C08L7/02A61K8/042A61K8/21A61Q11/00
Inventor A·杰哈T·斯蒙顿
Owner DENTSPLY SIRONA INC
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