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Aggregation-induced luminescent polyphosphate and synthesis method thereof

A technology of aggregation-induced luminescence and polyphosphate, applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of complex characterization methods, achieve good biocompatibility, no solvent, and controllable structure

Active Publication Date: 2019-12-06
NORTHWESTERN POLYTECHNICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, there are no reports on the fluorescence properties of polyphosphates, which makes the characterization of polyphosphates loaded with genes complicated.

Method used

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  • Aggregation-induced luminescent polyphosphate and synthesis method thereof
  • Aggregation-induced luminescent polyphosphate and synthesis method thereof
  • Aggregation-induced luminescent polyphosphate and synthesis method thereof

Examples

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Effect test

example 1

[0031] The preparation method of hydroxyl-terminated hyperbranched polyphosphate: Under the protection of nitrogen, triethyl phosphate (27.32g) and ethylene glycol (14.90g) are reacted at a molar ratio of 1:1.6. After adding the sample, the temperature is slowly raised to 130°C , and stirred at this temperature, reacted for 10 hours, dissolved the product in ethanol, dialyzed, rotary evaporated, and dried in vacuum to obtain a hydroxyl-terminated hyperbranched polyphosphate.

example 2

[0033] The preparation method of hydroxyl-terminated hyperbranched polyphosphoramide: under the protection of nitrogen, triethyl phosphate (27.32g) and ethylene glycol (16.76g) were reacted at a molar ratio of 1:1.8. After adding the sample, the temperature was slowly raised to 130°C , and stirred at this temperature, reacted for 10 hours, dissolved the product in ethanol, dialyzed, rotary evaporated, and dried in vacuum to obtain a hydroxyl-terminated hyperbranched polyphosphate.

example 3

[0035] The preparation method of hydroxyl-terminated hyperbranched polyphosphate: under the protection of nitrogen, triethyl phosphate (27.32g) and ethylene glycol (18.62g) react at a molar ratio of 1:2, after adding the sample, slowly raise the temperature to 130°C , and stirred at this temperature, reacted for 10 hours, dissolved the product in ethanol, dialyzed, rotary evaporated, and dried in vacuum to obtain a hydroxyl-terminated hyperbranched polyphosphate.

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Abstract

The invention relates to an aggregation-induced luminescent polyphosphate and a synthesis method thereof. The hydroxyl-terminated hyperbranched polyphosphate or linear polyphosphate is obtained by reacting a phosphate or phosphite with a dihydric alcohol or a trihydric alcohol according to a certain molar ratio through a simple ester exchange polycondensation method. The synthesized polyphosphatecan emit bright blue fluorescence under irradiation of ultraviolet light. Under irradiation of light with different wavelengths, fluorescent light with different wavelengths can be emitted, and the fluorescent light emitted by the synthesized polyphosphate can cover almost the whole range of visible light. The synthesized hyperbranched polyphosphate has a property of delaying fluorescence, and thefluorescence lifetime reaches a microsecond level. The synthesized hyperbranched polyphosphate has an aggregation-induced luminescence characteristic. The method has the characteristics of simple process, controllable structure, no need of solvents, environmental friendliness and the like. The synthesized polyphosphate has good biocompatibility, biodegradability, easy modification and the original aggregation-induced luminescence characteristic, so that the synthesized polyphosphate has wide application prospects in the aspects of DNA / RNA transport, cell imaging, drug delivery and the like.

Description

technical field [0001] The invention belongs to the field of polymer luminescent materials, and relates to an aggregation-induced luminescent polyphosphate and a synthesis method thereof, including hyperbranched polyphosphate or linear polyphosphate. Background technique [0002] In recent years, with the continuous enhancement of people's awareness of environmental protection, non-traditional fluorescent polymers without large π-conjugated structures such as benzene rings have good biocompatibility, biodegradability and environmental protection because they do not contain structures such as benzene rings. Friendliness has attracted extensive attention from academia and industry. These polymers can emit fluorescence under certain conditions, and have broad application prospects in the fields of cell fluorescence imaging, gene carrier and drug controlled release. As a new type of polymer, polyphosphate has been widely used in the fields of DNA / RNA delivery and flame retardan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G79/04C08G83/00C09K11/06
CPCC08G79/04C08G83/005C09K11/06C09K2211/14
Inventor 颜红侠王莲莲杨鹏飞朱城运李婉清
Owner NORTHWESTERN POLYTECHNICAL UNIV
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