Medical instrument

A technology of medical devices and adherents, which is applied in the field of medical devices, can solve the problems of weakening digestive function and defense function, particle disintegration or slow dissolution rate, inconvenient transportation and storage, etc., to reduce equipment, accelerate release, and easy operation Effect

Inactive Publication Date: 2019-12-20
万平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use the principles of obesity surgery, diabetes surgery and duodenal cannula (inner covering film) to locate the adherents (agents) in the duodenum, among which: in liquid or partially liquid form, its adhesion uniformity, release Both the degree of density and spreading are better than those of solids, but there are many preparation and operation units, high cost, inconvenient transportation and storage, liquids are easily corrupted and mildewed, and more preservatives are needed, and the specific surface area of ​​dispersed particles increases, resulting in a series of physical stability problems; liquids Or part of the liquid and its non-localized adhesion, deviates from the mechanism of obesity surgery, diabetes surgery and duodenal lining, and increases the dosage, expands and generalizes the absorption of nutrients, The digestive function and defense function of the stomach are weakened; the bioadhesive material is prepared into a non-liquid solid adhesive for positioning the duodenum, because it is difficult to solve the problem of powder (powder) materials, especially powder bioadhesive materials. Mutual adhesion (powder fluidity [velocity index, bow index, concave index, rebound index, relative binding index, compressibility index, strength index, etc.] is poor, especially in the non-dry environment entering the duodenum, very It is easy to self-adhesive and coagulate and consolidate), so the granulation link is often added in the operation unit, that is, after making granules and then filling or re-compressing, this not only increases the operation, equipment and cost, but also increases the disintegration or dissolution rate of the granules. Slower than powder, the adhesion in the duodenum is also reduced; if the particles are irregular spherical, the fluidity will be reduced instead

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Hypromellose (HPMC) 950mg, croscarmellose sodium (CCNa) 40mg, passed through a 200 mesh sieve (No. 9 Pharmacopoeia sieve), equal volume doubling and mixing, the fluidity of the powder affects the weight difference of the capsule, Content uniformity and normal operation are greatly affected. Adding 2.5% glidant micro-powder silica gel can prevent self-adhesion and wall-sticking, filling, enteric-coated capsule shell is made of edible water-soluble pure vegetable hypromellose production. Check the appearance: observation under natural light or full-spectrum light, the difference in loading and the determination of release rate and the results are all in line with the provisions of the General Rules of the Pharmacopoeia of the People's Republic of China (2015 Edition).

Embodiment 2

[0012] Hypromellose (HPMC) 950mg, croscarmellose sodium (CCNa) 40mg, the powder is less than or equal to 100μm, the same amount is multiplied and mixed, the fluidity of the powder affects the weight difference, content uniformity and normality of the capsule The operation has a great impact. Adding 2.5% glidant micro-powder silica gel can prevent self-adhesion and sticking to the wall. A small amount of lubricant magnesium stearate can be added, tableted, coated, and the coating material is made of edible water-soluble Made of pure vegetable hypromellose. Check the appearance: observation under natural light or full-spectrum light, the difference in loading and the determination of release rate and the results are all in line with the provisions of the General Rules of the Pharmacopoeia of the People's Republic of China (2015 Edition).

Embodiment 3

[0014] Hypromellose (HPMC) 950mg, croscarmellose sodium (CCNa) 40mg, pass through 200 mesh sieve (No. 9 Pharmacopoeia sieve) or less than or equal to 100μm powder, multiply and mix in equal amounts, the fluidity of the powder is good for the capsule The weight difference, content uniformity and normal operation of the agent are greatly affected. Adding 2.5% glidant micro-powder silica gel can prevent self-adhesion and wall-sticking, granulate, or fill into enteric-coated capsules, or compress tablets, and coat , Enteric-coated capsules or coating materials are made of edible water-soluble pure vegetable hypromellose. Check the appearance: observation under natural light or full-spectrum light, the difference in loading and the determination of release rate and the results are all in line with the provisions of the General Rules of the Pharmacopoeia of the People's Republic of China (2015 Edition). With the powder filling of above-mentioned embodiment, powder tabletting (or onl...

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PUM

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Abstract

A positioning adhesive is used for preparing a medical instrument for preventing or treating diabetes, obesity, duodenum inflammation or ulcer to replace application of products such as weight losingsurgery, diabetes surgery, duodenum cannula (internal tectorial membrane), isolating membranes and fluid directors in the medical instrument. At least one part of the biocompatible adhesive is in a powder solid state and at least one part is positioned and adhered to duodenum.

Description

[0001] This application can be a Chinese invention patent dated May 5, 2012 (application number 201210136379.X), August 21, 2012 (application number 201210298363.9), January 28, 2013 (application number 201310029525.3), March 31, 2013 Date (application number 201310107770.1), July 18, 2013 (application number 201310301366.8), January 4, 2016 (application number 201610001029.0), June 20, 2019 (application number 201910538674.X) and July 13, 2019 The series of applications filed on 201910632479.3, and the partial continuation of the PCT published on July 31, 2014 (WO2014 / 114255, PCT / CN2014 / 071294) and its corresponding national patents. technical field [0002] The present invention relates to a medical device (mainly preventing and treating diseases through physical and non-pharmacological methods), in particular to a replacement for bariatric surgery, diabetes surgery, duodenal cannula (inner coating), isolation membrane tube, flow guide, etc. Application of the product in med...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/32A61P3/10A61P1/04
CPCA61K9/4866A61P1/04A61P3/10
Inventor 万平
Owner 万平
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