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Method for detecting 16 kinds of local anesthetic components in adult external products

A detection method and local anesthesia technology, applied in measuring devices, material separation, analysis of materials, etc., can solve the problems of no uniform quality standards for adult external use products, and achieve the effects of strong practicability, simple operation process, and improved sensitivity

Active Publication Date: 2019-12-20
广东省药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no uniform quality standard for adult topical products. In order to ensure the follow-up research and production quality of adult topical products, it is necessary to carry out quality control on the anesthetic components of adult topical products.

Method used

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  • Method for detecting 16 kinds of local anesthetic components in adult external products
  • Method for detecting 16 kinds of local anesthetic components in adult external products
  • Method for detecting 16 kinds of local anesthetic components in adult external products

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Experimental program
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Embodiment 1

[0032] High performance liquid chromatography analysis method

[0033] Instruments and conditions:

[0034] Shimadzu LC 20-AT high performance liquid chromatography (with diode array detector). Methanol is chromatographically pure; phosphoric acid, dipotassium hydrogen phosphate and sodium heptanesulfonate are analytically pure. The ingredients of local anesthesia are listed in Table 1.

[0035] Table 1.16 Local Anesthetic Standard Substances

[0036]

[0037]

[0038] Chromatographic column: Agilent Poroshell 120EC-C18 (50mm×4.6mm, 2.7μm);

[0039] Flow rate: 1.5mL / min;

[0040] Column temperature: 35°C;

[0041] Injection volume: 10μL;

[0042] The wavelength range of qualitative analysis is 200-400nm, the wavelength of quantitative analysis is 210nm (lidocaine, prilocaine, ropivacaine, bupivacaine and pramoxine) and 280nm (procainamide, procaine chloroprocaine, benzocaine, buprocaine, oxybucaine, tetracaine, eugenol, dibucaine, eugenol formaldehyde and isoeugen...

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Abstract

The invention discloses a high-performance liquid chromatography method for detecting 16 kinds of local anesthesia components in adult external products, which is detected by the high-performance liquid chromatography method. The detection method includes the following steps: first preparing the test solution; then testing the test solution by using the high-performance liquid chromatography; within using a sub-3 micron core-shell packing chromatography column, which is suitable for the detection of 16 kinds of local anesthesia components. Through the setting of the chromatographic column andthe chromatographic analysis conditions, the invention improves the sample processing, improves the detection recovery rate and accuracy , makes the operation process simpler and faster, significantlyimproves the sensitivity of the detection method, has strong practicability, and provides support for the prevention and control of residues of 16 kinds of local anesthetic ingredients in adult external products.

Description

technical field [0001] The invention belongs to the field of drug analysis and detection, and relates to a detection method for 16 kinds of local anesthetic components in adult external products. Background technique [0002] With the improvement of people's living standards, there are more and more types of adult products. After years of inspections, the non-addition phenomenon of oral aphrodisiac products has been controlled, but some external products for adults such as lubricating oil, wet wipes and delay sprays have not been effectively supervised. Unscrupulous businesses will use adult products externally and illegally add local anesthetic ingredients to make huge profits. Long-term heavy use by consumers may cause adverse reactions such as dizziness, muscle twitching, and numbness of limbs, and may even cause serious consequences such as epilepsy and cardiac arrhythmia, endangering consumers' physical and mental health. [0003] Local anesthetics are a class of drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 黄艳婷庄玥邱蕴绮
Owner 广东省药品检验所