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A kind of preparation method of camphor essential oil soluble powder

An essential oil, soluble technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of volatile, easy discoloration and instability, and restricting the application of camphor essential oil, etc. , to achieve the effect of no precipitation, wide range of uses and fast dissolution speed

Active Publication Date: 2021-05-18
HENAN SOAR VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But camphor essential oil is insoluble in water, easy to volatilize, easy to change color and unstable, which limits the application of camphor essential oil in daily life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A preparation method of camphor essential oil soluble powder, the steps are as follows:

[0017] (a) Weigh 33.4 kg of camphor essential oil and 66.8 kg of absolute ethanol into the liquid mixing tank, stir and dissolve to obtain material liquid A; weigh 66.6 kg of calix[4]arene and 400 kg of purified water into the reaction kettle , stirred and dissolved to obtain feed liquid B; then feed liquid A was added to feed liquid B, and mixed evenly to obtain feed liquid C;

[0018] (b) Use an ultrasonic instrument to sonicate the material liquid C at a frequency of 40 Hz for 2 hours to obtain the material liquid D;

[0019] (c) Vacuum-dry the material liquid D at 50 °C, and the dried product is the soluble powder of camphor essential oil.

[0020] Powder fluidity: measured by the fixed cone method, take this product and place it in a funnel fixed above the center point of a circular vessel, which is a shallow petri dish with a known radius (5 cm). The powder flows out from t...

Embodiment 2

[0023] A preparation method of camphor essential oil soluble powder, the steps are as follows:

[0024] (a) Weigh 10 kg of camphor essential oil and 10 kg of absolute ethanol into the liquid mixing tank, stir and dissolve to obtain material liquid A; weigh 30 kg of gum arabic powder and 160 kg of purified water into the reaction kettle , stirred and dissolved to obtain feed liquid B; then feed liquid A was added to feed liquid B to obtain feed liquid C;

[0025] (b) Use an ultrasonic instrument to sonicate the material liquid C at a frequency of 20 Hz for 2 hours to obtain the material liquid D;

[0026] (c) Vacuum-dry the material liquid D at 40 °C, and the dried product is the soluble powder of camphor essential oil.

[0027] Powder fluidity: the method is the same as in Example 1. The average value of the angle of repose of the camphor essential oil soluble powder obtained in the present embodiment is 23 degrees.

[0028] Dissolution speed: take 0.5 g to 100 ml of this p...

Embodiment 3

[0030] A method for preparing camphor essential oil soluble powder, the steps are as follows:

[0031] (a) Weigh 20 kg of camphor essential oil and 20 kg of absolute ethanol into the liquid mixing tank, stir and dissolve to obtain material liquid A; weigh 80 kg of calix[4]arene and 300 kg of purified water into the reaction kettle , stirred and dissolved to obtain feed liquid B; then feed liquid A was added to feed liquid B to obtain feed liquid C;

[0032] (b) Use an ultrasonic instrument to sonicate the material liquid C at a frequency of 30 Hz for 2 hours to obtain the material liquid D;

[0033] (c) Vacuum-dry the feed liquid D at 45 °C, and the dried product is the soluble powder of camphor essential oil.

[0034] Powder fluidity: the method is the same as in Example 1. The average value of the angle of repose of the camphor essential oil soluble powder obtained in the present embodiment is 22 degrees.

[0035] Dissolution speed: Take 0.3 g to 100 ml of this product in...

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Abstract

The invention belongs to the field of veterinary medicine and discloses a preparation method of a soluble powder of camphor essential oil. The camphor essential oil is dissolved in absolute ethanol to obtain material liquid A; the solidified carrier is dissolved in water to obtain material liquid B; material liquid A and material liquid B are mixed evenly to obtain material liquid C; wherein, in terms of mass ratio, camphor essential oil: Absolute ethanol=1:(1~2), camphor essential oil:solidified carrier=1:(2~4), water:total mass of camphor essential oil and solidified carrier=(2~4):1; The solidification carrier is one of calixarene and gum arabic, or a mixture of the two; the material liquid C is ultrasonically obtained to obtain the material liquid D; the material liquid D is vacuum-dried, and the dried product is the soluble powder of camphor essential oil. The invention screens out the unique solidification carrier of camphor essential oil, and invents the soluble powder of camphor essential oil; the invention is a solid soluble powder with a low angle of repose, good powder fluidity, fast dissolution speed, no stratification and no precipitation , easy to use and widely used.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a preparation method of a soluble powder of camphor essential oil. Background technique [0002] The properties of camphor essential oil are yellow liquid, which is the essential oil extracted from the leaves, branches, roots, flowers and fruits of the camphor tree. The annual production of camphor essential oil in my country reaches 46% of the world's total output. Studies have confirmed that camphor essential oil has bactericidal, analgesic, anti-inflammatory and anti-oxidant effects. Cinnamomum camphor essential oil can accumulate active oxygen in the bacteria, generate oxidative stress, cause cell structure damage, and eventually cause bacterial death. According to reports, camphor essential oil has a certain inhibitory effect on Escherichia coli, vaginella vulgaris and Staphylococcus aureus. Some scholars have found that camphor essential oil has inhibitory e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K36/54A61K47/06A61K47/36A61P31/10A61P31/04
CPCA61K9/145A61K9/146A61K36/54A61P31/04A61P31/10
Inventor 胡帅罗显阳李凌峰岳贺赵硕磊高贵超陈佩格
Owner HENAN SOAR VETERINARY PHARMA
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