Indaconitone sand fried product, preparation method and application thereof

Abstract

The invention provides a compound shown as formula I in the specification or salt thereof. Specifically, R1 is selected from hydrogen, C1-C8 alkyl, C1-C8 alkoxy, halogen and -OC(O)R2; and R2 is selected from C1-C8 alkyl. According to the invention, the compound mithracitine separated from an indaconitone processed product not only does not cause arrhythmia, but also has excellent treatment effecton arrhythmia, can be used for preparation of drugs treating arrhythmia, and also can greatly reduce the toxicity of aconitum drugs containing indaconitone, thus having good application prospects.

Description

Technical field [0001] The present invention belongs to the field of medicinal chemistry, and specifically relates to a stir-fried product of indomethacin and its preparation method and application. Background technique [0002] Ranunculaceae (Ranunculaceae) Aconitum L. plant is a kind of important medicinal plants, mainly for the treatment of bruises, rheumatism, low back pain and other diseases. There are more than 300 species in the world, distributed in the temperate regions of the northern hemisphere; there are more than 200 species in my country, mainly distributed in the high mountains of western Sichuan, northern Yunnan and eastern Tibet, as well as in the northeast, northwest and Inner Mongolia, 40 of which are available for medicinal use , Such as Chuanwu A.carmichaelii / Radix, Northern Aconitum A.kusnezoffiiReichb., Huanghua Aconitum A.coreanum (H.Lév.) Rapaics, Brachypodum Diels, A. pendulum Busch, Kangding Aconitum tatsienense Finet&Gagnep. etc. But Aconitum plants co...

AI Technical Summary

Problems solved by technology

However, the processing principle of the sand frying method has not been fully elucidated, how the structure of the toxic alkaloid is transformed during the sand frying process, and whether the toxicity of the transformed product is reduced compared with the prototype alkaloid is not yet clear

And because the processing principle of the sand-frying method has not been clarified, the quality of the sand-stir-fried products is still judged by subjective experience such as "the outer skin is browned and the cross-section is yellow", and there is a lack of quantitative quality control indicators.

[0005] In addition, studies have shown that although some diterpene alkaloids have similar structures, their toxicity and efficacy are different. For example, some can cause arrhythmia and have cardiotoxicity, while others have the effect of treating arrhythmia.

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