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A kind of vitamin E solid tablet and preparation method thereof

A vitamin and tablet technology, applied in the directions of antidote, pill delivery, pharmaceutical formulation, etc., can solve problems such as insecurity, side effects, and poor comfort

Active Publication Date: 2021-09-10
SHANDONG FOOD & FERMENT IND RES & DESIGN INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the current vitamin E is a capsule containing vitamin solution. Due to the limitation of processing technology, the existing vitamin solid tablet is not comfortable to take. It is not only unsafe to take for a long time, but also has side effects.

Method used

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  • A kind of vitamin E solid tablet and preparation method thereof
  • A kind of vitamin E solid tablet and preparation method thereof
  • A kind of vitamin E solid tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The vitamin E solid tablets of this embodiment include the following materials: hydroxypropylene cellulose: 50 parts, vitamin E: 1.5 parts, maltodextrin: 45.1 parts, white sugar: 2 copies, microcrystalline cellulose : 1, ethyl maltol: 0.1 parts, magnesium stearate: 0.2 parts and Aspa: 0.1.

[0030] The vitamin E solid tablets described in this example are prepared by the following steps:

[0031] S1, all of the raw materials are added to the mixer for sufficient stirring;

[0032] S2, granulation: granulation of mixed original excipient in step S6 is granulated by manifold;

[0033] S3, a tablet: The pellets in step S7 are pressed via a tablet machine to prepare a vitamin E solid tablet.

Embodiment 2

[0035] The vitamin E solid tablets of the present embodiment include the following materials with a weight part of the meter: Purlanocyanate of octadeyl octadecyl acid: 42 parts, vitamin E: 1.6 parts, maltodextrin: 53, white Cumsum: 2 serviles: 1 crystalline cellulose: 1 part, ethyl maltol: 0.1 parts, stearate: 0.2 parts and Aspa: 0.1. Among them, the chemical molecular formula of the propullanopolysucanate of octadecylodamic acid is:

[0036]

[0037] The vitamin E solid tablets described in this example are prepared by the following steps:

[0038] S1, swelling: Puullanocyanate of octadecyloin ankanoacid is added to water, and the proportion of Pulan polysucanate and water of octadecylodectanoate is 1: 25, and the length of 5 h is swollen. A solution, the first solution is;

[0039] S2, mixing: The raw material vitamin E is added to the first solution in step S1, and the mixture is stirred at a high speed stirred disperser for 30 min, and the working speed of the disperser is ...

Embodiment 3

[0047]Purlanocyanate of eodeteganoyan acid: 45, vitamin E: 2.0, maltodextrin: 49.6 copies, white sugar: 2 copies, microcrystalline cellulose: 1 part, ethyl maltol: 0.1 Series, magnesium stearate: 0.2 parts and Aspen: 0.1.

[0048] The vitamin E solid tablets described in this example are prepared by the following steps:

[0049] S1, swelling: Puullanocyanate of octadecyloin ankanoacid is added to water, and the proportion of Pulan polysucanate and water of octadecylodectanoate is 1: 25, and the length of 5 h is swollen. A solution, the first solution is;

[0050] S2, mixing: The raw material vitamin E is added to the first solution in step S1, and the mixture is stirred at a high speed stirred disperser for 30 min, and the working speed of the disperser is 1200 r / min, and the second solution is obtained;

[0051] S3, high pressure homogenesis: The vitamin E dispersion in step S2 is high pressure homogeneous by high pressure homogers, and the high pressure homogeneous machine has...

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Abstract

The invention discloses a vitamin solid tablet and a preparation method thereof. The invention provides a vitamin E solid tablet, which comprises the following raw materials in weight fraction: octadecanoyl octadecanoate pullulan ester 40‑ 45 parts, vitamin E1.5‑2.0, 45‑55 parts of maltodextrin, and the balance is auxiliary materials. The present invention also provides a preparation method of vitamin E solid tablet, the preparation method comprising the following steps: S1, swelling; S2, mixing; S3, high pressure homogenization; S4, remixing; S5, spray drying; S6, mixing ; S7, granulation; S8, tabletting. The vitamin E solid tablet provided by the present invention has a more uniform hygienic element E content in each solid tablet, which can make the daily vitamin intake of the eater more balanced, and the structure of the vitamin E solid tablet of the present invention Firm, not easy to collapse, melts in the mouth when eating, no discomfort.

Description

Technical field [0001] The present invention relates to the field of preparation of vitamin E, and more particularly to a vitamin E solid tablet and a preparation method thereof. Background technique [0002] Natural vitamin E (VE) is a fat-soluble vitamin, also known as platyl, is a commonly used drug and health products, one of the most important natural antioxidants. Dissolules in extractants such as fat and isobutane, insoluble in water, stable heat, acid, acid is unstable, sensitive to oxygen, irritating heat, but the divergent vitamin E activity is significantly reduced. Placephenol can promote sex hormone [0003] Upper, enabling men's sperm vitality and quantity; enhances women's female estrogen concentration, improve fertility, prevent abortion, can also be used to prevent male infertility, burns, frostic, capillary bleeding, menopausal syndrome, beauty, etc. Good curative effect. Recently, vitamin E can also inhibit the peroxide reaction in the eye crystalline, and expa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K47/12A61K47/22A61K31/355A61P39/06
CPCA61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K31/355A61P39/06
Inventor 孙曙光兰文忠冀利苏理贺晓芳
Owner SHANDONG FOOD & FERMENT IND RES & DESIGN INST
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