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Oral liquid for increasing sperm and nourishing kidney and preparation method of oral liquid

An oral liquid and kidney-tonifying technology, which is applied in the field of Tianjing Bushen-tonifying oral liquid and its preparation, can solve the problems of reducing the curative effect of drugs, less extraction amount, and difficult to measure, and achieve the effects of good curative effect, high bioavailability, and convenient administration

Inactive Publication Date: 2020-01-07
BEIJING JIUFA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The Tianjing Tonifying Kidney Ointment prepared by the prior art "Pharmacopia of the People's Republic of China" has the following deficiencies: (1) all other 14 medicinal materials are decocted with water except tortoise shell glue and deer horn glue, and the fat-soluble active ingredients in some medicinal materials cannot be extracted come out or the amount of extraction is very small, which reduces the curative effect of the drug; (2) the product is a decoction, and the dosage is 9g at a time. When the patient takes it, it is difficult to measure, which brings inconvenience to the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] prescription:

[0032] Raw materials: Codonopsis 270g, Polygala 270g, Epimedium 270g, Radix Astragali 270g, Poria cocos 270g, Dog spine 270g, Cistanche 270g, Rehmannia glutinosa 360g, Angelica 270g, Morinda officinalis 270g, Eucommia ulmoides 270g fried with salt, Lycium barbarum 270g , 270g steamed Cynomorium, Sichuan Achyranthes bidentata 270g, tortoise shell glue 270g, deer horn glue 180g

[0033] Excipients: 300g of sucrose, 100g of propylene glycol, 10g of benzoic acid, appropriate amount of water, prepared into 10L.

[0034] Preparation:

[0035] 1. Take the prescription amount of polygala, add 95% ethanol for reflux extraction twice, add 8 times the amount of ethanol for the first time, reflux extraction for 2 hours, add 6 times the amount of 95% ethanol for the second time, reflux extraction for 1 hour, and combine twice The ethanol extract is filtered with a 250-mesh sieve, the ethanol is recovered from the filtrate and concentrated to a clear ointment with a...

Embodiment 2

[0042] prescription:

[0043] Raw materials: Codonopsis 270g, Polygala 270g, Epimedium 270g, Radix Astragali 270g, Poria cocos 270g, Dog spine 270g, Cistanche 270g, Rehmannia glutinosa 360g, Angelica 270g, Morinda officinalis 270g, Eucommia ulmoides 270g fried with salt, Lycium barbarum 270g , 270g steamed Cynomorium, Sichuan Achyranthes bidentata 270g, tortoise shell glue 270g, deer horn glue 180g

[0044] Excipients: stevia 0.5g, hydroxypropyl-β-cyclodextrin 50g, sodium benzoate 20g, prepared into 11L.

[0045] Preparation:

[0046] 1. Take the prescription amount of polygala, add 95% ethanol for reflux extraction twice, add 8-10 times of ethanol for the first time, reflux for 1-2 hours, add 6-8 times of 95% ethanol for the second time, reflux for extraction For 0.5-1 hour, combine the two ethanol extracts, filter, recover the ethanol from the filtrate and concentrate it to a clear ointment with a relative density of 1.15-1.20 at 55-60°C to obtain Polygala Alcohol Extracti...

Embodiment 3

[0053] prescription:

[0054] Raw materials: Codonopsis 270g, Polygala 270g, Epimedium 270g, Radix Astragali 270g, Poria cocos 270g, Dog spine 270g, Cistanche 270g, Rehmannia glutinosa 360g, Angelica 270g, Morinda officinalis 270g, Eucommia ulmoides 270g fried with salt, Lycium barbarum 270g , 270g steamed Cynomorium, Sichuan Achyranthes bidentata 270g, tortoise shell glue 270g, deer horn glue 180g

[0055] Excipients: 50g of lactose, 20-200g of cyclodextrin, 10g of sorbic acid, appropriate amount of water, made into 12L.

[0056] Preparation:

[0057] 1. Take the prescription amount of polygala, add 95% ethanol for reflux extraction twice, add 8-10 times of ethanol for the first time, reflux for 1-2 hours, add 6-8 times of 95% ethanol for the second time, reflux for extraction For 0.5-1 hour, combine the two ethanol extracts, filter, recover the ethanol from the filtrate and concentrate it to a clear ointment with a relative density of 1.15-1.20 at 55-60°C to obtain Polygal...

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PUM

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Abstract

The invention relates to oral liquid for increasing sperm and nourishing kidney and a preparation method of the oral liquid. In order to make up the defect of preparation of Pharmacopoeia of People'sRepublic of China, pharmacopoeia of the people's republic of China in the prior art, and based on the condition that treatment effect is high and the oral liquid is convenient to take for patients, the invention relates to a liquid preparation. Based on sufficient theoretical research and pharmacology research on various medicinal materials in the formula, the invention relates to a preparation method. The liquid preparation can be prepared into two kinds of oral liquid preparations including a sugar-containing oral liquid preparation and a sugar-free oral liquid preparation. The prepared preparation has the advantages of being high in biological availability, good in treatment effects, convenient to take and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparation technology research and development, and in particular relates to Tianjing Bushen Oral Liquid and a preparation method thereof. Background technique [0002] The health of the kidneys shows the vitality of the human body’s growth, development, and reproductive system. Tonifying the kidney and strengthening yang is a long-standing topic of men’s health. They usually eat some medicines or foods that invigorate the kidney and strengthen yang from time to time, but kidney deficiency is mostly caused by long-term accumulation. [0003] Tianjing Tonifying Kidney Ointment is a classic kidney-tonifying medicine, which has the functions of warming the kidney and supporting yang, and nourishing essence and blood. It is mainly used for diseases such as weakness of the waist and knees caused by deficiency of kidney yang and insufficient essence and blood, listlessness, chills and fear of cold, impote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/08A61K47/10A61K47/26A61P1/14A61K35/32A61K35/586
CPCA61K9/0095A61K35/32A61K35/586A61K36/076A61K36/12A61K36/185A61K36/21A61K36/232A61K36/296A61K36/344A61K36/46A61K36/481A61K36/64A61K36/69A61K36/746A61K36/804A61K36/815A61K47/10A61K47/26A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P1/14A61K2300/00
Inventor 刘玉泉柏吉哲
Owner BEIJING JIUFA PHARMA