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Composition for preventing enveloped virus infection and its preparation method and application

A technology of virus infection and composition, which is applied in the field of composition for preventing enveloped virus infection and its preparation, can solve the problems of easy mutation of virus and difficulties in clinical disease prevention and treatment, achieve strong inhibitory and killing effects, wide range of antiviral effects, Guarantee the effect of normal production

Active Publication Date: 2021-09-24
广州白云山宝神动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the actual clinical diagnosis and treatment process of veterinarians, viruses often mutate easily, which brings a certain degree of difficulty to clinical disease prevention and treatment

Method used

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  • Composition for preventing enveloped virus infection and its preparation method and application
  • Composition for preventing enveloped virus infection and its preparation method and application
  • Composition for preventing enveloped virus infection and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～5

[0093] The specific data of component composition weight ratio among the embodiment 1~5 is as shown in Table 1:

[0094] Table 1 Component composition table in Embodiments 1 to 5

[0095]

[0096]

[0097] Specific preparation process:

[0098] (1) According to the weight ratio of the formula, weigh A component, B component, C component, and D component respectively, and make each component mix uniformly, and set aside;

[0099] (2) Add disodium ethylenediamine tetraacetate to the uniformly mixed component D in an amount of 5-25g / kg, stir and mix uniformly, and prepare premixture E;

[0100] (3) Add a surfactant in the prepared premix E, the addition amount is 5-25g / kg, after stirring and mixing uniformly, the premix F is prepared;

[0101] (4) Add vitamin E and vitamin C to the prepared premixture F, the amount of vitamin E added is 5-50 g / kg, the amount of vitamin C added is 5-50 g / kg, after stirring and mixing uniformly, the premix G is prepared;

[0102] (5) In tu...

Embodiment 6

[0105] The toxicological test of the composition for preventing enveloped virus infection is as follows:

[0106] Acute toxicity test:

[0107] Experimental observation, because the LD50 cannot be measured, so the determination of the maximum dosage was carried out. The compositions for the prevention of enveloped virus infection prepared in Examples 1-5 were formulated into oral liquids using physiological saline or glucose, and were directly administered to mice. The results showed that the maximum drug administration concentration was 11.84 crude drug / ml, and the maximum administration volume 50ml / kg was intragastrically administered to mice twice within 24 hours, and the maximum dose of the drug administered to mice was 400g crude drug / kg. No adverse reaction or death occurred in the animals, and no abnormalities were found in the organs under anatomical observation.

[0108] Long-term toxicity test:

[0109] In this experiment, 200 SD rats were used, and the composition...

Embodiment 7

[0111] In this example, in order to verify the preventive effect of the composition for preventing enveloped virus infection of the present invention on poultry viral diseases, based on the components provided in Examples 1-5, the following experiments were carried out:

[0112] 1. Prevention of Newcastle disease infection

[0113] 1. Selection of experimental animals: 300 chicks at the age of 25 days.

[0114] 2. Experimental drugs and equipment:

[0115] Newcastle disease virus, scales, scientific calculator.

[0116] 3. Experimental grouping and processing:

[0117] Randomly divided into 6 groups, 50 pigeons in each group, the classification and treatment of each group are as follows:

[0118] Five test groups:

[0119] Prepare the composition for preventing enveloped virus infection provided by Examples 1-5, add it to the diet, feed it to chickens, and drink water freely for 15 days;

[0120] A control group:

[0121] The chickens were fed with normal rations and had...

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Abstract

The invention discloses a composition for preventing enveloped virus infection. According to the infection characteristics initiated by animal host cells such as enveloped virus adsorption and invasion, tea polyphenols (tea leaf extract), light bamboo leaf extract, rosemary Extract, Moringa extract, Hedyotis diffusa extract and other natural plant extracts are mainly antioxidants, and at the same time compound suitable fat-soluble antioxidants and excipients to prepare a "green, organic, safe, and pollution-free" available The composition is used for preventing envelope virus infectious diseases of animals or livestock and poultry, so as to fill in the passive situation that in the actual production process of livestock and poultry breeding, there is no medicine to prevent viral diseases of livestock and poultry except vaccines. Therefore, the patented invention is useful for ensuring the normal production of the livestock and poultry breeding industry, especially for the enveloped virus disease that currently has no vaccine to prevent it, or the viral disease with a low vaccine protection rate, or the remedial measures for the failure of livestock and poultry immunity, etc. Prevention and treatment are of great practical significance.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a composition for preventing enveloped virus infection, a preparation method and application thereof. Background technique [0002] Viruses are intracellular parasites, and their replication must rely on the biomacromolecule synthesis mechanism and energy of the host cell. In terms of chemical composition, viruses are mainly composed of nucleic acids and proteins. Some complex viruses, especially animal viruses, contain lipids, carbohydrates and a small amount of other components in addition to nucleic acids and proteins. [0003] Nucleic acid is the genetic material of the virus, and proteins form the capsid that wraps the nucleic acid. Some viral capsids are also coated with lipid membranes from the host. The virus has a simple structure and does not have the nucleus, cytosol, organelles, cell membrane and other structures that typical animal and plant cells have....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61K36/899A61P31/14A61P31/20A61P31/22A61P31/04A61P37/04A23K10/30A23K20/163A23K20/105A23K20/10A23K20/111A61K31/05A61K31/085A61K31/47A61K31/235A61K31/375A61K31/194A61K31/19
CPCA61K31/05A61K31/085A61K31/19A61K31/194A61K31/235A61K31/375A61K31/47A61K36/185A61K36/53A61K36/748A61K36/82A61K36/899A23K10/30A23K20/10A23K20/105A23K20/111A23K20/163A61P31/04A61P31/14A61P31/20A61P31/22A61P37/04A61K2300/00
Inventor 廖海标李城丰
Owner 广州白云山宝神动物保健品有限公司
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