Application of Metrnl in atherosclerosis (AS) resistance

A kind of atherosclerosis, agonist technology, applied in the field of medicine
CN110694049APending Publication Date: 2020-01-17THE NAVAL MEDICAL UNIV OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE NAVAL MEDICAL UNIV OF PLA
Publication Date
2020-01-17

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Abstract

The invention relates to novel application of Metrnl, belongs to the technical field of medicine and in particular relates to application of the Metrnl in atherosclerosis (AS) resistance. A Metrnl<- / ->ApoE<- / -> double-knockout mouse AS model and an EC-Metrnl<- / ->ApoE<- / -> mouse AS model are constructed, experiments show that the severity of AS of the two Metrnl knockout mice is higher than that ofcontrol mice, reflected in that aortas of the Metrnl knockout mice havemore atherosclerotic plaques than those of control mice, the area ratio of the atherosclerotic plaques of the aortas of the Metrnl knockout mice is higher than that of control mice, the thickening degree and inflammatory infiltration degree of root atherosclerosis of the aortas of the Metrnl knockout mice are higher than thoseof control mice and the expression level of inflammatory factors of the aortas of the Metrnl knockout mice is increased. The invention proves that the Metrnl can be applied to AS resistance by experimentsfor the first time.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of Metrn1 in anti-atherosclerosis. Background technique

[0002] Atherosclerosis (AS), as the common pathological basis of cardiovascular and cerebrovascular diseases, has long been one of the focuses and hotspots in the field of cardiovascular disease research, and AS is also the main cause of cardiovascular disease disability and death. Therefore, how to prevent and treat AS is very important for the treatment of patients with cardiovascular disease and the improvement of long-term prognosis.

[0003] Metrnl, also known as Subfatin, Cometin, and Interleukin39, is a new type of adipokine discovered by our laboratory (Miao Chaoyu’s research group) in recent years. It is highly expressed in subcutaneous adipose tissue and intestinal epithelial tissue, and is a homologous protein with Meteorin, but Expression distribution and function are quite different. At pres...

Claims

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