Effective sensitivity of a photodetector of an image sensor is controlled by partitioning signal charge from incident photons, thus producing a manageable yield and a consequently higher, photon shot noise limited, signal to noise ratio than in the prior art, when imaging high flux rates of energetic photons or particles, such as produced by x-ray generators. The invention may be applied, for example, to an image sensor with a photosensitive layer coupled to a charge collection/readout structure, e.g. photoconductor or scintillator on CMOS array, or to an intrinsically sensitive charge collection/readout structure, e.g. deep active layer CMOS. A radiation sensor pixel structure 10 for use in the invention includes a photodetector 11, a transfer gate 131 for controlling charge collection from the photodetector and a dump drain 12 controlled by a dump gate 121, arranged for selectively dumping charge to the dump drain means and collecting charge from the photodetector means, in a duty cycle 31, for varying effective sensitivity of the pixel structure. An image sensor containing such pixel structures may selectively be operated in an integration mode or a photon counting mode. Preferably the image sensor has imaging pixels and control circuitry arranged on a same semiconductor die, such as a CMOS semiconductor die.