The invention discloses an X-ray detector and a manufacturing method thereof. The X-ray detector comprises an interconnection substrate, bonding interconnection, a photovoltaic conversion device chip and a CMOS pixel reading chip, wherein the bonding interconnection penetrates through the interconnection substrate and is exposed out of the two main surfaces of the interconnection substrate, the photovoltaic conversion device chip is bonded with one main surface of the interconnection substrate, the CMOS pixel reading chip is bonded with the other main surface of the interconnection substrate, and a bonding pad of the photovoltaic conversion device chip is electrically connected with a bonding pad of the CMOS pixel reading chip through the bonding interconnection. According to the X-ray detector, working processes can be simplified, and reliability and yield can be improved.