Effective sensitivity of a 
photodetector of an 
image sensor is controlled by partitioning 
signal charge from incident photons, thus producing a manageable yield and a consequently higher, 
photon shot noise limited, 
signal to 
noise ratio than in the prior art, when imaging 
high flux rates of energetic photons or particles, such as produced by x-
ray generators. The invention may be applied, for example, to an 
image sensor with a photosensitive layer coupled to a charge collection / readout structure, e.g. photoconductor or 
scintillator on 
CMOS array, or to an intrinsically sensitive charge collection / readout structure, e.g. deep 
active layer CMOS. A 
radiation sensor pixel structure 10 for use in the invention includes a 
photodetector 11, a transfer gate 131 for controlling charge collection from the 
photodetector and a dump drain 12 controlled by a dump gate 121, arranged for selectively dumping charge to the dump drain means and collecting charge from the photodetector means, in a 
duty cycle 31, for varying effective sensitivity of the pixel structure. An 
image sensor containing such pixel structures may selectively be operated in an integration mode or a 
photon counting mode. Preferably the image sensor has imaging pixels and control circuitry arranged on a same 
semiconductor die, such as a 
CMOS semiconductor die.