A hot forging and pressing mold of a large inside hexagonal bolt blank comprises an upper template, an upper mold base plate, an upper fixing plate, an elastic body, an upper forming plate, an upper male mold, a first forming plate, a second forming plate, an ejector rod sleeve plate, an auxiliary ejector rod sleeve plate, a lower mold base plate, a lower template, an ejector rod, an auxiliary ejector rod and an auxiliary plate. A first hole is arranged on the ejector rod sleeve plate, a downward-convex hexagon head is arranged in the middle of the lower end of the upper male mold, a concave cambered surface used for molding a fillet on a bolt head is arranged at the circumferential edge of the lower end of the upper male mold, and an annular first chamfer surface is arranged at the connection position of the hexagon head and the upper male mold. A bolt head forming hole is arranged on the first forming plate, a bolt rod forming hole used for bolt rod forming is arranged on the second forming plate, diameters of the bolt head forming hole, the bolt rod forming hole and the first hole are reduced successively, a second chamfer surface is arranged at the upper end of the first hole, and a cooling water channel is arranged in the first forming plate. The hot forging and pressing mold of the large inside hexagonal bolt blank has the advantages of being capable of once forming the bolt blank and being high in production efficiency and long in service life.