Preparation method and application of compound preparation with effect of human aldose reductase inhibitor
A technology of reductase inhibitor and compound preparation, applied in the field of prevention and treatment of diabetic retinopathy
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Embodiment 1
[0026] Preparation of tablets based on 500g:
[0027] a. Grind 10 parts of aloe vera, 20 parts of Xun Luxiang, and 5 parts of Heguo vine root respectively, and pass the crude drug powder through a 60-mesh sieve for later use;
[0028] b. Add 20 parts of rose petals, 5 parts of myrobalan, and 10 parts of Tribulus terrestris to 12 times the amount of water, extract 2 times, extract 3 hours each time, combine, and obtain the water extract for later use;
[0029] c. Add 30 parts of cumin to 6 times the amount of water, extract by steam distillation for 6 hours, obtain the extract for later use, and collect the volatile oil;
[0030] d. Stir each part of volatile oil with 4 parts of β-cyclodextrin at 30°C for 1 hour, refrigerate at 4°C for 12 hours, filter, dry at 50°C, and pass through a 60-mesh sieve to obtain the inclusion compound of volatile oil for later use;
[0031] e. Combine the cumin extract obtained in step c with the extracts of rose petals, myrobalan and Tribulus ter...
Embodiment 2
[0034] Preparation of tablets based on 500g:
[0035] a. Grind 25 parts of aloe vera, 10 parts of Xunluxiang, and 5 parts of Heguo vine root respectively, and pass the crude drug powder through a 100-mesh sieve for later use;
[0036] b. Add 10 parts of rose petals, 15 parts of myrobalan, and 15 parts of Tribulus terrestris to 10 times the amount of water, extract 2 times, extract 3 hours each time, and obtain the water extract for later use;
[0037] c. Add 20 parts of cumin to 8 times the amount of water, extract by steam distillation for 5 hours, obtain the extract for later use, and collect the volatile oil;
[0038] d. Stir each part of volatile oil with 5 parts of β-cyclodextrin at 30°C for 0.5h for clathrate, refrigerate at 4°C for 12h, filter, dry at 50°C, and pass through a 100-mesh sieve to obtain volatile oil clathrate for later use ;
[0039] e. Combine the fennel extract obtained in step c with the extracts of rose petals, myrobalan and Tribulus terrestris obtai...
Embodiment 3
[0042] Preparation of tablets based on 500g:
[0043] a. Grind 10 parts of aloe vera, 20 parts of Xunluxiang, and 5 parts of Heguo vine root respectively, and pass the crude drug powder through a 50-mesh sieve for later use;
[0044] b. Add 5 parts of rose petals, 10 parts of myrobalan, and 20 parts of Tribulus terrestris to 8 times the amount of water, extract 3 times, extract 2 hours each time, and obtain the water extract for later use;
[0045] c. Add 30 parts of cumin to 10 times the amount of water, extract by steam distillation for 4 hours, obtain the extract for later use, and collect the volatile oil;
[0046] d. Mix each part of volatile oil with 6 parts of β-cyclodextrin at 30°C for 1 hour, refrigerate at 4°C for 12 hours, filter, dry at 50°C, and pass through a 50-mesh sieve to obtain the inclusion compound of volatile oil for later use;
[0047] e. Combine the fennel extract obtained in step c with the extracts of rose petals, myrobalan and Tribulus terrestris ob...
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