Preparation method and application of rabbit alveolar bone defect model

An alveolar bone and rabbit tooth technology, which is applied in the field of biomedicine, can solve the problems such as the application evaluation of bone implant materials has not been disclosed in patents, it is not conducive to the reconstruction mechanism of the lower alveolar bone, and it cannot effectively imitate the alveolar bone defect. Economical and practical, clear marking points, regular border effects

Inactive Publication Date: 2020-01-31
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former cannot effectively imitate the alveolar bone defect histologically, and the bone wall of the mandibular ramus is thin, so the bone graft material is not easy to fix; the latter is easy to damage the tooth root when preparing extreme defects, which affects the chewing function of animals, which is not conducive to simulating normal chewing. Alveolar bone reconstruction mechanism
[0004] According to the literature search, there is no patent publication on the method of using the edentulous area of ​​the rabbit mandible to prepare the animal model of alveolar bone defect and its application in bone implant materials.

Method used

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  • Preparation method and application of rabbit alveolar bone defect model
  • Preparation method and application of rabbit alveolar bone defect model
  • Preparation method and application of rabbit alveolar bone defect model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 A kind of preparation method of rabbit alveolar bone defect model

[0036] see figure 1 , a method for preparing a rabbit alveolar bone defect model through the following steps:

[0037] (1) weighing and anesthetizing New Zealand white rabbits with a body weight of 2.5-3.0kg, male or female; Perform ear vein injection; local anesthesia with 2% lidocaine along the mental foramen.

[0038] (2) Fix the New Zealand rabbit in the lateral position, and carry out skin preparation and disinfection treatment on the rabbit; the scope of the skin preparation treatment is from the submandibular area to the masseter muscle area;

[0039] (3) After local anesthesia in the mental foramen area, in the edentulous mandibular area, 2 mm from the lower edge of the mandible, an extraoral parallel incision was made on the alveolar bone surface. The length of the incision was 1.5 cm, and the soft tissue was bluntly separated layer by layer. Exposure field and strip the periost...

Embodiment 2

[0042] (1) Animals

[0043] New Zealand white rabbits, August, 2.5-3.0kg, male or female.

[0044] (2) Equipment and materials

[0045] Conventional periodontal surgery instruments, slow motors and straight heads, slow split drills, ball drills, anesthetics, disinfection drugs, operating room consumables, etc.

[0046] (3) Method

[0047] 1. No feeding before operation: Animals should not be fed with water for 24 hours before operation.

[0048] 2. The animal is weighed and fixed in the rabbit frame.

[0049] 3. Anesthesia: Inject 1% sodium pentobarbital into the ear vein at a dose of 3 mg / kg.

[0050] 4. Skin preparation: After proper anesthesia, shave the hair inside and around the mouth, and disinfect with povidone-iodine after cleaning.

[0051] 5. Fixation: The rabbit is placed in the supine position, the limbs are tied to the special test bench, the head is pulled to the side, the incisors of the rabbit are fixed on the head of the test bench with a rope, and the eden...

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Abstract

The invention discloses a preparation and application of a rabbit alveolar bone defect model. An edentulous area is used for preparing non-boring deossification, the price is low relatively, an alveolar bone is similar to a human alveolar bone, and when being used for preparing an animal alveolar bone model, the preparation method has good economy and practicality. A standard jaw defect model which is clear in marking points, regular in borders, good in repeatability and quantizable is established. The modelling success rate is high, the preparation method is simple to operate and easy to duplicate, the ossification promoting properties of materials can be effectively evaluated, further a reliable imaging and histology evidence can be provided for screening and evaluation of various bone transplantation materials, and the application range is broad.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the preparation of a rabbit alveolar bone defect model and a method for evaluating the bone-promoting performance of a bone graft material by using the model. [0002] technical background [0003] Cranio-maxillofacial trauma, tumors, inflammation and other factors can lead to alveolar bone defects, and then loose teeth and fall off, affecting the normal oral function of patients, which has become one of the most common clinical problems. With the improvement of people's living standards and medical awareness, more and more patients seek alveolar bone defect repair to stabilize natural teeth, accommodate implants, facilitate denture restoration, and restore dentition function and facial shape. The research and development of ideal bone graft materials and the realization of alveolar bone regeneration have increasingly become a hot and difficult point in stomatology research. For all kind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 雷利红俞媛媛陈莉丽韩佳吟
Owner ZHEJIANG UNIV
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