A kind of extraction and purification method of cannabidiol

A technology of cannabidiol and purification methods, which is applied in chemical instruments and methods, organic chemistry, bulk chemical production, etc., can solve the problems of inability to fully remove heavy metal residues, cannabidiol safety adverse reactions, and end product safety. Avoid hidden dangers and other problems, and achieve the effect of narrow dissolution spectrum, easy access, and fast drying speed

Active Publication Date: 2022-07-05
黑龙江龙麻工业大麻二酚提取有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The extraction process in the prior art cannot fully achieve the removal of heavy metal residues, pesticide residue impurities, etc., so that there are hidden dangers in the safety of the final product, and it also has a certain negative impact on the purity of the product. The highest purity can only reach 98%. Obtaining substances with higher purity and lower impurities can also easily lead to chemical reactions between cannabidiol and other components during the extraction process, reducing the extraction yield, and the practical application field is relatively limited
[0004] It can be seen that the quality basis of the existing technology for the final product only regards the extraction cost and purity as the purpose of extraction, and does not regard the removal of heavy metal residues, pesticide residues, organic solvent residues and impurities introduced during the extraction process as an important part of the process. This will instead affect the purity of the final product and produce unpredictable adverse reactions to the safety of cannabidiol in the fields of medicine, health care products and cosmetics

Method used

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  • A kind of extraction and purification method of cannabidiol
  • A kind of extraction and purification method of cannabidiol
  • A kind of extraction and purification method of cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Dry the cannabis flowers, leaves or seed coats with a hot air circulating bellows at 120°C to a moisture content of not more than 6%;

[0031] (2) pulverize the dried cannabis flower, leaf or seed coat to a particle size of 100 mesh;

[0032] (3) Use supercritical argon extraction method to extract the crushed cannabis flowers, leaves or seed coats, the extraction temperature is 20 ° C, and the stage pressure control method is used to make the argon pressure reach the supercritical state of 30 MPa, and the extraction time is 5 hours, the desorption temperature is 20 °C, and the desorption pressure is 10 MPa to obtain cannabis extract;

[0033] (4) adopt molecular distillation method, the cannabis extract obtained in step (3) is distilled 5 times, and distillation temperature is 180 ℃, and vacuum tightness is 10Pa, obtains crude cannabis oil;

[0034] (5) the crude hemp oil obtained in step (4) is dissolved with 12 times of weight of ethanol or methanol, and argon s...

Embodiment 2

[0037] (1) Dry the cannabis flowers, leaves or seed coats with a hot air circulating air box at 60°C to a moisture content of not more than 6%;

[0038] (2) pulverize the dried cannabis flower, leaf or seed coat to a particle size of 20 mesh;

[0039] (3) Use supercritical argon extraction method to extract the crushed cannabis flowers, leaves or seed coats, the extraction temperature is -70 ° C, and the stage pressure control method is used to make the argon gas pressure reach the supercritical state of 5MPa, and the extraction time is 0.5 hours, the desorption temperature is -70°C, and the desorption pressure is 1MPa to obtain hemp extract;

[0040] (4) adopt molecular distillation method, the cannabis extract obtained in step (3) is distilled 2 times, the distillation temperature is 115 ℃, and the vacuum tightness is 0.5Pa, obtains crude cannabis oil;

[0041] (5) the crude hemp oil obtained in step (4) is dissolved with 6 times of weight of ethanol or methanol, and argon ...

Embodiment 3

[0044] (1) Dry the cannabis flower, leaf or seed coat with a hot air circulating air box at 150°C to a moisture content of not more than 6%;

[0045] (2) pulverize the dried cannabis flower, leaf or seed coat to a particle size of 100 mesh;

[0046](3) Use supercritical argon extraction method to extract the crushed cannabis flowers, leaves or seed coats, the extraction temperature is 40 ° C, and the stage pressure control method is used to make the argon pressure reach the supercritical state of 50 MPa, and the extraction time is 5 hours, the desorption temperature is 20°C, and the desorption pressure is 20MPa to obtain hemp extract;

[0047] (4) adopt molecular distillation method, the cannabis extract obtained in step (3) is distilled 5 times, the distillation temperature is 220 ℃, and the vacuum tightness is 20Pa, obtains crude cannabis oil;

[0048] (5) the crude hemp oil obtained in step (4) is dissolved with 20 times of weight of ethanol or methanol, and argon supercri...

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Abstract

The invention discloses a method for extracting and purifying cannabidiol. Cannabis flowers, leaves or seed coats are first dried and pulverized, then extracted by supercritical argon extraction method, and then preliminarily separated by molecular distillation method, and finally by argon supercritical argon extraction method. Separation and purification by critical fluid chromatography to obtain high-purity cannabidiol. The purification and extraction method of the invention greatly improves the extraction yield of cannabidiol, and the purity of the final product, the organic solvent residue and the pesticide residue are significantly improved compared with the existing products. Security provides assurance.

Description

technical field [0001] The invention relates to a method for extracting and purifying cannabidiol, which belongs to the technical field of extracting medicinal components. Background technique [0002] Cannabis (Cannabis sativa L.), also known as hemp, mountain silk seedling, thread hemp, etc., is an annual herb of the Moraceae Cannabis genus. Because of its component tetrahydrocannabinol (THC), which has mental and physiological activities after smoking or oral administration, it can make people excited, hallucinogenic, damage the nervous system, and has a certain degree of addiction. Therefore, it is allowed to grow in my country. It is industrial hemp, and the content of its chemical constituent THC is required to be lower than 0.3%; cannabidiol (CBD) is a non-psychoactive substance existing in hemp, which has good neuroprotective, anti-inflammatory, antioxidant, Anti-tumor effect, anti-liver injury effect and immune regulation are widely used in the fields of medicines, h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C37/68C07C39/23C07C37/74C07C37/82
CPCC07C37/82C07C37/68C07C37/74C07C39/23Y02P20/54
Inventor 张树权李国辉肖挽
Owner 黑龙江龙麻工业大麻二酚提取有限公司
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