Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

3D printing antibacterial hydrogel wound dressing based on green in-situ reduction

A 3D printing and wound dressing technology, applied in 3D object support structures, additive manufacturing, medical science, etc., can solve the problems of weak antibacterial performance of antibacterial hydrogel, potential safety hazards in the preparation method, and inability to meet antibacterial requirements, etc., to achieve reduction Effects of potential cytotoxicity, excellent antibacterial properties, and high water absorption

Active Publication Date: 2020-02-07
CHINA UNIV OF MINING & TECH
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The existing wound dressings also have the following disadvantages: (1) poor moisturizing ability, easy to adhere to the wound surface; (2) the antibacterial performance of single-component antibacterial hydrogel is weak, and cannot meet the complex antibacterial requirements in clinical practice; (3) nanometer Silver itself has potential cytotoxicity, and the preparation method has potential safety hazards; (4) The raw materials for preparing hydrogels and the use of reagents in the preparation process have potential safety hazards; (5) The mechanical properties are generally poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction
  • 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction
  • 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] The invention discloses a preparation method of a 3D printed antibacterial hydrogel wound dressing based on green in situ reduction. The preparation materials include: raw materials for reducing nano-silver: gelatin, silver nitrate; raw materials for constructing hydrogel: polyvinyl alcohol, chitosan, gelatin, deionized water; raw materials for cross-linking hydrogel: sodium citrate.

[0029] Such as figure 1 As shown, the preparation process:

[0030] (1) prepare nanometer silver-gelatin solution;

[0031] (2) prepare polyvinyl alcohol / chitosan / gelatin solution;

[0032] (3) Prepare the solution to be printed;

[0033] (4) 3D printing hydrogel on non-woven fabric;

[0034] (5) Cross-linking (freezing-thawing and soaking in sodium citrate) the sample prepared in step 4; thereby obtaining a silver-loaded polyvinyl alcohol / chitosan / gelatin hydrogel wound dressing.

[0035] The prepared hydrogel wound dressing figure 2 Shown, in line with the requirements of the ide...

Embodiment 1

[0038] 1) Reduction of nano-silver: dissolving gelatin in deionized water, heating in a water bath at 50° C. and fully stirring to obtain a gelatin solution with a mass fraction of 2%; preparing a silver nitrate solution with a mass fraction of 1%. The silver nitrate solution was added dropwise to the sodium alginate solution at a mass ratio of 3:100, reacted at 90°C in the dark for more than 10 hours, and stirred vigorously to obtain a yellow nano-silver-gelatin solution.

[0039] 2) Preparation of polyvinyl alcohol / chitosan / gelatin solution: Dissolve polyvinyl alcohol in deionized water, fully swell, heat and stir in a water bath at 95° C., and fully dissolve. Add acetic acid, chitosan, and sodium alginate, and stir evenly at 50° C. to obtain a polyvinyl alcohol / chitosan / gelatin solution.

[0040] 3) Preparation of the solution to be printed: Mix the nano-silver-gelatin solution and the polyvinyl alcohol / chitosan / gelatin solution at a volume ratio of 1:1, stir evenly, and re...

Embodiment 2

[0044] 1) Reduction of nano-silver: dissolving gelatin in deionized water, heating in a water bath at 50° C. and fully stirring to obtain a gelatin solution with a mass fraction of 2%; preparing a silver nitrate solution with a mass fraction of 1%. The silver nitrate solution was added dropwise to the sodium alginate solution at a mass ratio of 3:100, reacted at 90°C in the dark for more than 10 hours, and stirred vigorously to obtain a yellow nano-silver-gelatin solution.

[0045] 2) Preparation of polyvinyl alcohol / chitosan / gelatin solution: Dissolve polyvinyl alcohol in deionized water, fully swell, heat and stir in a water bath at 95° C., and fully dissolve. Add acetic acid, chitosan, and sodium alginate, and stir evenly at 50° C. to obtain a polyvinyl alcohol / chitosan / gelatin solution.

[0046] 3) Preparation of the solution to be printed: Mix the nano-silver-gelatin solution and the polyvinyl alcohol / chitosan / gelatin solution at a volume ratio of 1:1, stir evenly, and re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction. The 3D printing antibacterial hydrogel wound dressing is prepared from the following raw materials: a raw material used for reducing nano-silver: gelatin and silver nitrate; a raw material used for constructing the hydrogel is prepared from the following raw materials: polyvinyl alcohol, chitosan, gelatin and deionized water; and a raw material used for cross-linking the hydrogel: sodium citrate. The preparation process comprises the following steps: (1) preparing a nano-silver-gelatinsolution; (2) preparing polyvinyl alcohol / chitosan / gelatin; (3) preparing a solution to-be-printed; (4) performing 3D printing of hydrogel on the non-woven fabric; (5) cross-linking (freezing-unfreezing and soaking in sodium citrate) a sample prepared in the step (4), and obtaining the gelatin antibacterial hydrogel wound dressing. The prepared hydrogel wound dressing meets the requirements of ideal dressings.

Description

technical field [0001] The invention belongs to the technical field of wound dressings for human body, and in particular relates to a preparation method of a 3D printed antibacterial hydrogel wound dressing based on green in-situ reduction. Background technique [0002] The skin is the largest organ of the human body. It can protect the stability of the internal environment of the body and resist the invasion of the external environment. It has an important role in physical, chemical and biological barrier protection. When the skin is traumatized, it will cause a series of problems in the body. If it is not healed in time, it will cause a large loss of body fluid through the wound, leading to tissue necrosis and, in severe cases, life-threatening complications. Therefore, after skin damage, its integrity must be restored in time to re-establish homeostasis. [0003] Wound dressings can replace damaged skin to obtain temporary protection during wound healing and treatment, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L26/00A61L15/18A61L15/22A61L15/44A61L15/46B29C64/112B33Y10/00B33Y70/00
CPCA61L15/18A61L15/225A61L15/44A61L15/46A61L26/0066A61L26/008A61L26/0095A61L2300/104A61L2300/404A61L2300/604B33Y10/00B33Y70/00B29C64/112C08L89/00C08L29/04C08L5/08
Inventor 陈凯王丰艳吴晓芳刘思雨许林敏张德坤
Owner CHINA UNIV OF MINING & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com