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Preparation method of tablet of mycelium superfine powder of hirsutella hepiali

A technology of Trichosporum and Trichosporum of bat moth, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pill delivery, etc. Fast solution speed, insufficient absorption of oral chemical drug effect, etc., to achieve the effect of accelerating drug release and release speed, improving disintegration speed, and prolonging residence time

Inactive Publication Date: 2020-02-11
TIBET ZANGCAO YISHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although adopting this method can improve drug absorption, the oral buccal formulation of oral buccal tablets can effectively improve its absorption speed, but the above-mentioned existing preparation scheme has a fast disintegration speed, which cannot satisfy the disintegration requirements of oral buccal tablets. Speed ​​requirements, i.e. insufficient absorption of buccal drug effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of preparation method of the tablet of the superfine powder of Trichosporum mycelium of bat moth, comprises the following steps:

[0019] A, get Cordyceps sinensis fungus Trichosporium bat moth mycelium, adopt ultra-fine powder to crush and pulverize into particle size powder greater than 320 mesh and less than 398 mesh;

[0020] B, add 45g premix, 25g disintegrating agent in 300g Trichomonas batata mycelium powder, add binding agent and mix granulation and dry;

[0021] C. Add disintegrating agent and premix according to the method of equal amount addition, add it to peppermint oil ethanol solution, let it stand for more than 3 hours, shake it up, spray it evenly on the granules, ventilate and dry at room temperature, and press into granules.

Embodiment 2

[0023] This embodiment discloses a specific implementation manner, which includes the following steps:

[0024] A. Get the mycelia of the fungus Trichosporium bat moth from Cordyceps sinensis, and crush it into powder with a particle size of 374 meshes by using superfine powder.

[0025] B. Get 300g of Trichomonas batata mycelium powder, add 45g of premix, 25g of disintegrating agent, add binder, mix and granulate and dry. The premix is ​​glucose, sucrose, polyethylene glycol , filler, wherein 50-55 parts of glucose, 45-47 parts of sucrose, 1-2 parts of polyethylene glycol, 34-37 parts of filler.

[0026] C. Add the disintegrating agent and premix in the same amount incrementally. The premix and disintegrating agent in this step are consistent with those in step B. Add it to the ethanol solution of peppermint oil, and shake it up after standing for 3.5 hours. Spray it evenly on the granules, ventilate and dry at room temperature, and press into granules.

[0027] The tablet ...

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Abstract

The invention discloses a preparation method of a tablet of mycelium superfine powder of hirsutella hepiali. The preparation method includes the following steps that A, mycelium of the cordyceps fungus hirsutella hepiali is taken, and the superfine powder is used for breaking and pulverizing the mycelium into powder with particle size larger than 320 mesh and smaller than 398 mesh; B, 45 g of a premixed material and 25 g of a disintegrant are added into 300 g of the hirsutella hepiali mycelium powder, and an adhesive is added and mixed to be granulated and dried; and C, the disintegrant and the premixed material are mixed by additive in an equal quantity mode, and added into a peppermint oil ethanol solution, still standing is conducted for more than 3 hours, the mixture is shaken well, sprayed evenly on particles, ventilated and dried at the room temperature, and pressed into particles. The preparation method can increase the disintegration rate, prolongs stay time of agentia in an oral cavity, and improves absorption of effective components by oral mucosa, sublingual venous plexus and the like.

Description

technical field [0001] The invention relates to the field of preparation of Cordyceps sinensis health care products, in particular to a method for preparing a tablet of the ultrafine powder of Trichosporum mycelium of bat moth. Background technique [0002] The scientific name of the worms in Cordyceps sinensis is called bat moth larvae, and the scientific name of grasses is called Trichosporum sinensis. Cordyceps sinensis is a complex of Cordyceps fungus and bat moth larvae. The scientific name of the mycelium formed by the reproduction of the fungus in the worm is: Bat moth mycelium, commonly known as Cordyceps sinensis mycelium. The superfine powder of Trichosporum hyphae of bat moth is made into tablet for taking, and the powder is in the range of 400-1200 mesh, which is beneficial to the absorption of effective substances. Patent application number 201310075334.0 "Preparation method of superfine powder tablet of Trichosporum mycelium of the fungus Cordyceps sinensis" d...

Claims

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Application Information

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IPC IPC(8): A61K36/068A61K9/20A61K47/26A61K47/10
CPCA61K9/0056A61K9/2018A61K9/2031A61K36/068
Inventor 邓家忠
Owner TIBET ZANGCAO YISHENG BIOLOGICAL TECH CO LTD
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