A kind of hap-csa-sf composite gel material and its preparation method and application

A technology of composite gel and composite gel layer, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve the problems of poor toughness, low support performance, weak cartilage and bone integration, etc., and achieve high toughness and good effect Effect
CN110787323BActive Publication Date: 2020-11-24SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2020-11-24

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Abstract

The invention provides a HAp-CSA-SF composite gel material. The HAp-CSA-SF composite gel material comprises a chondroitin-sulfate silk-fibroin composite gel layer, as well as a hydroxyapatite-enrichedlayer arranged on at least one end face of the chondroitin-sulfate silk-fibroin composite gel layer; the hydroxyapatite-enriched layer is capable of repairing damaged inner-layer bone tissue, as wellas enhancing bonding strength between cartilages and adjacent bones, thereby ensuring that a repaired cartilage can function normally; and the chondroitin-sulfate silk-fibroin composite gel layer isintegrated gel made from chondroitin sulfate and silk fibroin. Moreover, along with degradation of the silk fibroin, the chondroitin sulfate can be synchronously released so as to further promote regeneration of cartilages, thereby realizing repair on the cartilages. By adopting a multiphase layered design, the HAp-CSA-SF composite gel material is capable of realizing rapid cartilage repair, as well as synchronously enhancing bonding strength between repaired cartilages and adjacent bones
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Description

technical field

[0001] The invention belongs to the technical field of cartilage tissue repair, and in particular relates to a HAp-CSA-SF composite gel material and its preparation method and application. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Cartilage tissue engineering is one of the important directions of tissue engineering. Cartilage plays an important role in the human body such as load bearing, power transmission and cushioning. The cartilage in the joints is the basis for maintaining the normal movement of the human body. However, cartilage wear and tear and cartilage damage caused by external forces occur from time to time, and can cause problems such ...

Claims

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