Synthesis method of 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compound

A technology of aniline compounds and synthesis methods, which is applied in the direction of electrolysis process, electrolysis components, electrolysis organic production, etc., can solve the problems of lack of application value, long reaction time, low efficiency, etc., and achieve the green environmental protection of the preparation process and short reaction time Effect
CN110846675AActive Publication Date: 2020-02-28FUYANG NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUYANG NORMAL UNIVERSITY
Publication Date
2020-02-28

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Abstract

The invention discloses a synthesis method of a 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compound. The method comprises the following steps: respectively adding an electrolyte, substituted isatin, substituted benzoyl hydrazine, a solvent, an alkali and an electrode into a non-separated electrolytic cell, and carrying out electrifying and stirring for a reaction; and subjecting a solution obtained after the reaction to separating and purifying so as to obtain the 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compound. According to the method, no metal or chemical oxidant is needed in the preparation process; reaction time is short; and the preparation process is green and environmentally friendly.
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Description

technical field

[0001] The invention relates to the technical field of synthesis of aniline compounds, in particular to a synthesis method of 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compounds. Background technique

[0002] 2,5-Diaryl-1,3,4-oxadiazoles are an important class of oxygen-containing heterocycles, which widely exist in bioactive molecules and optoelectronic materials. In particular, 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compounds, due to the presence of amino groups in their molecules, provide the possibility for further conversion into useful organic molecules. Therefore, its synthesis has always been the research focus of organic chemists. However, due to the compatibility of amino groups in the system, there are few reports on 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compounds.

[0003] In 2015, Wu's group synthesized 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compounds (C . Xu, F-C. Jia, Q. Cai, D-K. Li, Z-W. Zhou and A-X. Wu, Chem. Commun, 2015, 51, 6629.). Alt...

Claims

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