Chitosan quaternary ammonium salt antibacterial gel and preparation method thereof

Abstract

The invention belongs to the technical field of medical drugs, and discloses chitosan quaternary ammonium salt antibacterial gel and a preparation method thereof. The chitosan quaternary ammonium saltantibacterial gel is prepared from the following components in parts by weight: 90-99.9 parts of chitosan quaternary ammonium salt, 0.01-10 parts of organic acid and 1-5 parts of a cross-linking agent; the preparation method comprises the following steps: (1) dissolving the chitosan quaternary ammonium salt into the deionized water in parts by weight, adding the organic acid after stirring and dissolving, and continuously stirring and mixing the materials; (2) weighing a cross-linking agent, dissolving the cross-linking agent into deionized water, slowly dropwise adding the cross-linking agent into the mixed solution obtained in the step (1), magnetically stirring and uniformly mixing, and continuously reacting the materials in a constant-temperature incubator to obtain the gel; and (3) taking out the gel, washing with ethanol, and freeze-drying the material to obtain the chitosan quaternary ammonium salt antibacterial gel. The novel chitosan quaternary ammonium salt gel provided by the invention has relatively good swelling property and pH responsiveness, has relatively strong antibacterial property on gram-negative and gram-positive bacteria, is simple in preparation process andlow in cost, and is expected to become a novel wound gel dressing.

Description

technical field [0001] The invention belongs to the technical field of medical drugs, and relates to a chitosan quaternary ammonium salt antibacterial gel and a preparation method thereof. Background technique [0002] Gel dressing is a new type of wound dressing developed in recent years. Compared with traditional gauze, gel has better biocompatibility. To a certain extent, it blocks external bacterial infection, effectively prevents the loss of body fluids, and can deliver enough oxygen to the wound to accelerate wound healing. Therefore, research on gel as a new type of dressing is becoming more and more extensive. However, although most gels can provide a better healing environment, their antibacterial effect is insufficient. At present, most of the research on improving the antibacterial performance of gels is by adding substances with strong antibacterial activity to the gel materials, such as silver ions, antibiotics, iodine, etc., but each of these has its own disad...

AI Technical Summary

Problems solved by technology

However, although most gels can provide a better healing environment, their antibacterial effect is insufficient

At present, most of the research on improving the antibacterial performance of the gel is by adding substances with strong antibacterial activity to the gel material, such as silver ions, antibiotics, iodine, etc., but each of these has its own disadvantages

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