Method for determining cvortioxetine intermediate and its isomers by using liquid chromatography

A technology of isomers and determination methods, which is applied in the directions of measuring devices, material separation, and analysis materials, etc., can solve problems such as incomplete removal of isomers, side reactions, and influence on drug purity and quality, and achieve improvement Yield and purity, reduced side reactions, quality-controlled effects
CN110873760AInactive Publication Date: 2020-03-10万全万特制药(厦门)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
万全万特制药(厦门)有限公司
Publication Date
2020-03-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of analytical chemistry. The invention discloses an analysis method for separating and determining a vortioxetine hydrobromide intermediate and its isomers by usingliquid chromatography. The method uses a chromatographic column filled with phenyl bonded silica gel as a filler and a certain proportion of a buffer salt solution-organic phase as a mobile phase, andcan quantitatively determinethe content of the vortioxetine hydrobromide intermediate and isomers thereof so that the mass of a vortioxetine hydrobromide starting material is effectively controlled,side reactions are reduced, and therefore it is guaranteed that the quality of a vortioxetine hydrobromide final product is controllable. The method is strong in specificity, high in accuracy and simple and convenient to operate.
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Description

technical field

[0001] The invention belongs to the field of analytical chemistry, and in particular relates to a method for separating and measuring vortioxetine hydrobromide intermediate 2,4-dimethylthiophenol and its isomers by liquid chromatography. Background technique

[0002] Vortioxetine hydrobromide is an antidepressant with multiple pharmacological activities, which is clinically used to treat major depressive disorder and generalized anxiety disorder. The English name of vortioxetine hydrobromide is VortioxetineHydrobromide, and its chemical name is 1-[2-(2,4-methylphenylthio)phenyl]piperazine hydrobromide (1-[2-(2,4 -dimethyl-phenylsulfanyl)phenyl]-piperazinehydrobromide), molecular formula is C 18 h 22 N 2 S. HBr. Vortioxetine hydrobromide intermediate chemical name is 2,4-dimethylthiophenol; molecular formula is C 8 h 10 S. Vortioxetine hydrobromide intermediate structural formula is:

[0003]

[0004] Isomer 1 I...

Claims

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