A method for preparing multilayer polymer microneedles

A technology of polymers and polymer sheets, which is applied in the direction of microneedles, medical devices, needles, etc., can solve the problems of high preparation cost, complicated preparation process, and long preparation cycle, and achieve simple process operation, high micromachining precision, Effect of Controlling Drug Dissolution Rate

Active Publication Date: 2021-03-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of multi-layer microneedle can realize the superposition of different layers in a single needle body, which increases the types of drugs that can be loaded, but requires a complicated preparation process, and the preparation cycle is long and the preparation cost is also high.

Method used

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  • A method for preparing multilayer polymer microneedles
  • A method for preparing multilayer polymer microneedles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment provides a method for preparing a four-layer composite microneedle loaded with lidocaine and acetylspiramycin. The preparation method includes the following steps:

[0028] (1) Preparation of microneedle base layer: The mold used in the experiment is made of stainless steel, and 7×7 microneedle concave-shaped frustum-shaped arrays are distributed on the mold. (The major diameter of the truncated cone) is 0.25mm, the top diameter (the minor diameter of the truncated cone) is 0.05mm, and the depth is 0.55mm. Polylactic acid (PLA) is selected as the polymer material, and the glass transition temperature of PLA is 56°C. Place the microstructure mold and PLA sheet between the upper and lower mold bases of the micro-thermal embossing equipment, and then heat the mold and PLA sheet to a hot embossing temperature of 112°C; load the mold to press it into the softened PLA sheet In the process, adjust the pressure to 4.10MPa, and keep the pressure for a certain ti...

Embodiment 2

[0032] This embodiment provides a method for preparing a four-layer composite microneedle loaded with ibuprofen and gentamicin. The preparation method includes the following steps:

[0033] (1) Preparation of microneedle base layer: The mold used in the experiment is made of stainless steel, and 7×7 microneedle concave-shaped frustum-shaped arrays are distributed on the mold. (The major diameter of the truncated cone) is 0.25mm, the top diameter (the minor diameter of the truncated cone) is 0.05mm, and the depth is 0.55mm. The polymer material is polymethyl methacrylate (PMMA), and the glass transition temperature of PMMA is 105°C. Place the microstructure mold and PMMA sheet between the upper and lower mold bases of the micro-thermal embossing equipment, then heat the mold and PMMA sheet to a hot embossing temperature of 116°C; load the mold to press it into the softened PMMA sheet In the process, the pressure is adjusted to 7.08MPa, and the pressure is maintained for a cert...

Embodiment 3

[0037] This embodiment provides a method for preparing a four-layer composite microneedle loaded with albuterol and norfloxacin. The preparation method includes the following steps:

[0038] (1) Preparation of microneedle base layer: The mold used in the experiment is made of stainless steel, and 7×7 microneedle concave-shaped frustum-shaped arrays are distributed on the mold. (The major diameter of the truncated cone) is 0.25mm, the top diameter (the minor diameter of the truncated cone) is 0.05mm, and the depth is 0.55mm. Polycarbonate (PC) is selected as the polymer material, and the glass transition temperature of PC is 150°C. Place the microstructure mold and PC sheet between the upper and lower mold bases of the micro-thermal embossing equipment, and then heat the mold and PC sheet to a hot embossing temperature of 120°C; load the mold to press it into the softened PC sheet In the process, adjust the pressure to 10.00MPa, and keep the pressure for a certain period of ti...

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Abstract

The invention discloses a method for preparing a multilayer polymer microneedle, belonging to the field of microneedle transdermal drug delivery. According to the invention, an insoluble hard substrate microneedle is prepared by using a micro-hot embossing process; a drug solution is dried on the surface of a needle body of a microneedle in a multi-spraying manner; thus, a multi-layer drug structure is obtained. Meanwhile, sodium hyaluronate is coated onto the outer layer of the multi-layer drug structure, so a polymer microneedle with a substrate layer, a drug layer and a rapid release layeris obtained. Compared with a conventional microneedle, the microneedle provided by the invention can be stacked in multiple layers in a certain needle length range, so the variety of loadable drugs isincreased. And the insoluble substrate microneedle is prepared by utilizing the micro-hot embossing process, so simple process operation and high micromachining precision are realized, and the periodof preparation is greatly shortened. In addition, by changing of the thickness of outer-layer sodium hyaluronate, the purpose of controlling the dissolution speed of a drug is achieved.

Description

technical field [0001] The invention relates to a medical microneedle drug delivery system, in particular to a method for preparing multilayer polymer microneedles. Background technique [0002] Microneedles are a relatively new form of transdermal drug delivery. They generally consist of a group of 25-2000 μm long needle tips arranged on a base, and achieve the purpose of minimally invasive and painless drug delivery by piercing the stratum corneum of the skin. At present, from the perspective of materials, microneedles are mainly divided into silicon, metal or polymer microneedles. Because polymer microneedles have good biocompatibility, biodegradability, low toxicity, low processing cost and sufficient strength, they are expected to replace silicon and metal microneedles and have great development potential. At present, most polymer microneedles use a single type. Although single-type polymer microneedles have the advantages of good biocompatibility and simple manufactu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K45/00A61K47/36A61M37/00
CPCA61K9/0021A61K45/00A61K47/36A61M37/0015A61M2037/0046A61M2037/0053
Inventor 庄俭康婷婷吴大鸣杨振洲孙靖尧方以勒杜唯佳许红高小龙黄尧林龙
Owner BEIJING UNIV OF CHEM TECH
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