Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of L-theanine

A technology of theanine and glutamic acid, which is applied in the field of preparation of L-theanine, can solve the problems of low yield and low safety, and achieve the effects of simple post-processing, improved safety and easy acquisition.

Active Publication Date: 2020-03-24
浙江财和生物科技有限公司
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a preparation method of L-theanine to solve the technical problems of low safety and low yield in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of L-theanine
  • Preparation method of L-theanine
  • Preparation method of L-theanine

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] The reaction scheme of the preparation method of the present embodiment is as follows:

[0054]

Embodiment 1

[0056] The present embodiment provides a kind of preparation method of L-theanine, comprises the following steps:

[0057] (1) Add 20.0g of L-glutamic acid to a 500mL reaction vessel, add 100g of water, start stirring, add the prepared copper acetate aqueous solution dropwise at 30°C, continue to react for 0.5h after the dropwise addition, and then filter under reduced pressure , wash the precipitate with a small amount of water to obtain 22.8 grams of L-copper glutamate chelate (chelate A) crude product;

[0058] Wherein, the preparation method of copper acetate aqueous solution is: stirring and dissolving 16.3g of copper acetate monohydrate in 100g of water.

[0059] (2) Add the L-copper glutamate chelate crude product obtained in step (1) into a 500mL reaction vessel, add 160mL of methanol, add 16.0g of concentrated sulfuric acid with a mass fraction of 98% under stirring conditions, and add 16.0g of concentrated sulfuric acid at 30°C After reacting for 3 hours, the reacti...

Embodiment 2

[0064] The present embodiment refers to the preparation method of Example 1, the difference is only that step (3) is as follows:

[0065] The L-glutamic acid-5-methyl ester copper chelate crude product obtained in step (2) was added in a 500mL reaction vessel, 180g of water was added, and an aqueous solution of ethylamine (70% by mass) 24.0 g was added dropwise at 30°C. g, after reacting for 3 hours, add 30.3 g of EDTA disodium salt, then raise the temperature of the reaction solution to 60°C for 3 hours, stop the reaction, concentrate the water in the reaction solution to dryness, and obtain crude L-theanine;

[0066] Recrystallize the crude L-theanine with ethanol to obtain L-theanine; the specific recrystallization method includes: adding 160 g of ethanol to the crude L-theanine above, heating to reflux and stirring for 1-2 hours, and filtering while hot, After cooling and crystallization, filter and dry to obtain 19.0 g of L-theanine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of L-theanine. The preparation method of the L-theanine comprises the following steps:(a) reacting L-glutamic acid with a copper salt in a solvent to obtain a chelate A; (b) carrying out an esterification reaction on the chelate A and methanol to obtain a compound B; and (c) after a reaction of the compound B with an aqueous ethylamine solution is finished, adding a decoppering reagent, carrying out stirring for a reaction, and removing a solvent to obtain a crude L-theanine product. According to the preparation method of the L-theanine, the L-glutamic acid is used as an initial raw material and is easy to obtain; in addition, residues in amino acid are protected by adopting acopper chelate manner, so the reaction process is green and environment-friendly. In the step (c), the safer aqueous ethylamine solution is used for the reaction, so the safety of the reaction is improved, requirements on equipment are reduced, production cost is greatly saved, and industrial production is easier.

Description

technical field [0001] The invention relates to the technical field of organic chemical synthesis, in particular to a preparation method of L-theanine. Background technique [0002] L-Theanine (L-Theanine, whose structural formula is shown below) is a unique free amino acid in tea. Theanine is the main taste substance of tea. A series of pharmacological and health care functions such as immunity, enhancing learning and memory, lowering blood pressure, and anti-tumor. Therefore, the application prospect of L-theanine in food, health care products and other industries has received extensive attention. [0003] [0004] At present, the production methods of L-theanine mainly include chemical synthesis, fermentation and extraction. The extraction method is limited to raw materials, and its extraction cost is very high; biological fermentation has high requirements on equipment, strict condition control, and high cost; while the method of chemical synthesis is relatively sim...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C237/06
CPCC07C231/02C07C227/18C07B2200/07C07C237/06C07C229/76
Inventor 薛凌霄王明江世坤张文
Owner 浙江财和生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com