13 results about "Copper Chelation" patented technology

The application provides an amino acid composite reagent system and a method for treating electronic waste to prepare high-purity glycine copper, and belongs to the technical field of metal hydrometallurgy and resource recycling. The application builds an ammonia catalytic reduction mechanism by designing an amino acid composite reagent system, greatly improves the leaching rate, simultaneously inhibits the dual effects of copper hydroxide precipitation and glycine chelation, and realizes efficient solution of copper ions; through narrow window regulation technology of pH at 9.5±0.2, the stability of ammonia, the activity of glycine anion are maintained, and the selective leaching rate of copper is ensured; a directional crystallization process of leaching solution is constructed, the "self-assembly directional crystallization" process of glycine copper chelate is used, based on the saturation concentration of glycine copper in the leaching solution and the stable chelate structure, through three-stage crystallization precise regulation, the preparation of high-purity crystal is realized. The process realizes the closed-loop crystallization system of "zero addition of crystal seeds and zero wastewater discharge" of the copper-containing complex leaching solution of electronic waste.

The application discloses a chitosan-glycine-copper chelate and a preparation method and application thereof in treating leukoplakia and vitiligo. In the preparation, chitosan is first placed in an acid aqueous phase system, and is fully dissolved and forms a uniform transparent or translucent solution under stirring; then glycine is added, and the chitosan and the glycine are fully mixed under stirring to build an organic ligand environment containing multiple coordination groups; subsequently, a copper source is introduced to perform a chemical reaction, and finally the chitosan-glycine-copper chelate is obtained. The chitosan-glycine-copper chelate shows a strong promoting activity completely different from all other substances (including simple mixtures of components thereof), the chelate can continuously and significantly activate tyrosinase activity, and promote the formation of melanin, so that the purpose of treating leukoplakia and vitiligo is achieved.

Disclosed herein is the use of a copper chelating agent or an agent capable of inducing a copper chelating agent for the treatment of cancer, in particular for increasing the efficiency of an immunotherapy for the treatment of cancer. Disclosed herein are methods of treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of a copper chelating agent or a copper chelating agent inducer in combination with a therapeutically effective amount of an anti-cancer immunotherapeutic agent. Also disclosed herein are kits or combinations and compositions comprising a copper chelating agent or a copper chelating agent inducer and an anti-cancer immunotherapeutic agent, and uses thereof for the treatment of cancer.

The application discloses a protein anchoring type copper response photoacoustic probe and a preparation method and application thereof, the probe can be selectively chelated with copper in the mitochondria of tumor cells, so that the photoacoustic signal of the probe is activated, in-situ tracing and quantification of copper ions in the tumor are realized. Meanwhile, copper chelation realizes copper depletion in the mitochondria, causes damage to the structure and function of the mitochondria, and realizes diagnosis and treatment integration of the tumor. In addition, the probe can specifically react with protein sulfenic acid in the mitochondria to form a probe-protein conjugate, promote enrichment of the probe at the tumor site, prolong the imaging window and improve the treatment effect of copper depletion.

The application discloses a composition for improving mitochondrial activity and application thereof in cosmetics. The composition is prepared from a hyaluronic acid lysine copper chelate and an extract of European juniper berries. The composition can significantly promote the expression of NAD+, mitochondrial ATP and collagen III, and inhibit the expression of mitochondrial ROS, and has the effects of improving mitochondrial activity and effectively resisting aging, and can be used in cosmetics to improve skin relaxation and wrinkle problems.

The application discloses a skin care composition for improving skin redness and dryness and application. The composition of the application is compounded by hyaluronic acid lysine copper chelate, radix stephaniae tetrandrae extract and polygonatum extract. The composition can promote the expression of moisture retention related factors HAS1 and AQP3, and inhibit the expression of inflammation related factors PGE2 and TNF-alpha, so as to improve the skin redness and dryness. The composition is used in acid mud film, and the stability experiment shows that the composition can maintain the stability of the mud film product under low pH conditions, and the appearance is uniform. It is also found that the composition can greatly reduce the irritation of the acid mud film.

The invention discloses an enzymolysis gleditsia sinensis saponin-copper chelate as well as a preparation method and application thereof in prevention and treatment of citrus canker, and belongs to the technical field of crop prevention and treatment. The preparation method comprises the following steps: extracting gleditsia sinensis saponin, purifying the gleditsia sinensis saponin, carrying out enzymatic degradation on the gleditsia sinensis saponin, and then adding CuSO4. 5H2O to carry out chelation reaction to obtain the enzymolysis gleditsia sinensis saponin-copper chelate. The initial contact angle of an aqueous solution of the chelate on citrus leaves is small, the chelate can be rapidly wetted and spread on the leaves, the deposition effect is good, the chelate has excellent leaf adhesion performance and anti-scouring capacity, meanwhile, the enzymolysis gleditsia sinensis saponin-copper chelate has excellent inhibitory activity on xanthomonas carpesium, and the enzymolysis gleditsia sinensis saponin-copper chelate can be used for preparing the citrus leaf-copper chelate. The compound can be used as a green, environment-friendly, safe and efficient bactericide, and has excellent application potential in the aspect of citrus canker prevention and control.

The invention belongs to the cross technical field of nano medicine, tumor immunotherapy and chemotherapy, and discloses a novel copper chelating nano medicine and a preparation method thereof. The preparation method of the novel copper chelating nano-drug comprises the following steps: S1, firstly, carrying out sulfydryl addition reaction on a mitochondrial targeting group by utilizing mercaptopropionic acid to prepare a mercaptopropionic acid intermediate; s2, coupling the thiohydracrylic acid intermediate with a copper ion chelating group through an amidation reaction to obtain a compound IR-TIE; and S3, carrying out self-assembly on the obtained IR-TIE and albumin to form the IR-TIE coated Alb nanoparticles. The compound has accurate tumor mitochondrial targeting property, free copper ions of tumor cells can be effectively reduced at an extremely low dosage, so that IDO1 and LOX are reduced, innate immune activation is realized, tumor collagen crosslinking is reduced, tumor extracellular matrix is loosened, and medicine permeation is promoted.

The invention relates to the field of animal nutrition and feed additives, in particular to an organic copper chelate as well as a preparation method and application thereof. The preparation method of the organic copper chelate comprises the following steps: (1) mixing amino acid, algal polysaccharides, trace element copper and an optional catalyst in the form of dry powder, and then adding a wetting agent accounting for 2-5% of the total weight of the materials for wetting treatment; (2) carrying out a pressing reaction on the humidified material under heating and pressurizing conditions; and (3) granulating a product obtained after the pressing reaction. According to the method, amino acid and algal polysaccharides are used as double organic ligands and are subjected to complex reaction with trace element copper under the action of a catalyst, and meanwhile, a compression molding process is combined, so that continuous integrated operation of reaction and molding is completed in the same system; and the method has the advantages of simple process, no wastewater, no organic solvent, high operation safety, high production efficiency and the like.

The application discloses a skin care composition with keratinization envelope repairing effect and application thereof. The skin care composition is prepared by compounding Dendrobium candidum stem extract and / or Glycyrrhiza inflata Bat. extract on the basis of hyaluronic acid lysine copper chelate, and the skin care composition can promote filaggrin (FLG), involucrin (IVL), loricrin (LOR), keratin (KRT1) and keratinocyte transglutaminase (TGM1) protein expression, so that the effect of repairing keratinization envelope is achieved, and the skin care composition can be used for improving skin barrier and redness and other problems in cosmetics.

The invention relates to the technical field of wastewater treatment and recycling, and discloses modified chelate resin as well as a preparation method and application thereof. The method comprises the following steps: (1) sequentially carrying out first soaking, second soaking and third soaking on chelate resin in a first NaOH solution, an HCl solution and a second NaOH solution respectively, and carrying out suction filtration and drying to obtain pretreated resin; (2) mixing the pretreated resin with a CuSO4 solution to perform first contact reaction for 2-4 hours, and then sequentially performing washing, suction filtration and drying to obtain copper-loaded chelate resin; and (3) mixing the copper-loaded chelate resin with a third NaOH solution, carrying out second contact reaction for 5-30 minutes, and then sequentially washing, carrying out suction filtration and drying to obtain the modified chelate resin. The modified chelate resin obtained through the method has excellent regeneration performance and stability, the selective adsorption capacity of the chelate resin to target ions is improved, and meanwhile interference of coexisting ions is reduced.

The application discloses an enzymatic Gleditsia japonica saponin-copper chelate, a preparation method thereof and application thereof in the prevention and treatment of citrus canker, and belongs to the technical field of crop prevention and treatment. The Gleditsia japonica saponin is extracted, purified and degraded by an enzyme method, CuSO4*5H2O is added to perform a chelation reaction, and the enzymatic Gleditsia japonica saponin-copper chelate is obtained. The initial contact angle of the aqueous solution of the chelate on citrus leaves is small, the aqueous solution can rapidly wet and spread on the leaves, the deposition effect is good, the chelate has excellent leaf adhesion and anti-washing capacity, the enzymatic Gleditsia japonica saponin-copper chelate has excellent inhibitory activity on Xanthomonas axonopodis, can be used as a green, environmentally-friendly, safe and efficient bactericide, and has excellent application potential in the prevention and treatment of citrus canker.

This invention belongs to the interdisciplinary fields of nanomedicine, tumor immunotherapy, and chemotherapy, and discloses a copper chelate nanomedicine and its preparation method. The preparation method of the copper chelate nanomedicine includes the following steps: S1, firstly, a mercaptopropionic acid intermediate is prepared by performing a thiol addition reaction on a mitochondrial targeting group using mercaptopropionic acid; S2, secondly, the mercaptopropionic acid intermediate is coupled to a copper ion chelating group via an amidation reaction to obtain the compound IR-TIE; S3, the obtained IR-TIE is self-assembled with albumin to form IR-TIE@Alb nanoparticles. This invention exhibits precise tumor mitochondrial targeting, effectively downregulating free copper ions in tumor cells at extremely low doses, thereby downregulating IDO1 and LOX, achieving innate immune activation, reducing tumor collagen cross-linking, loosening the tumor cell extracellular matrix, and promoting drug penetration.