Double-sided intravascular stent with nitric oxide catalytic release function and preparation method of double-sided intravascular stent

Abstract

The embodiment of the invention provides a double-sided intravascular stent with a nitric oxide catalytic release function and a preparation method of the double-sided intravascular stent, and relates to the field of cardiovascular interventional therapy instruments. The double-sided intravascular stent comprises a stent body, the inner wall of the stent body is coated with an adhesion layer, a bionic pattern structure is carved on the outer wall of the stent body, and active drugs are arranged in the bionic pattern structure; the adhesion layer contains primary amino and o-phenolic hydroxyl, and the surface, away from the stent body, of the adhesion layer is grafted with a Cu chelate. The adhesion layer of the double-sided intravascular stent takes surface primary amino as a reaction site, copper chelate can be covalently grafted to catalyze release of NO based on carbodiimide chemical cross-linking reaction, a bionic pattern structure is engraved and constructed on the outer surface of the stent body through a laser technology, and a bioactive medicine with a complementary function with NO is loaded, so that the double-sided intravascular stent is prepared. NO can be stably released through synergistic cooperation of the inner surface and the outer surface of the stent body, and the functions of synergistic anticoagulation, anti-inflammation and diseased vascular tissue regeneration and repair promotion of the double-sided modified coating are creatively exerted.

Description

technical field [0001] The present application relates to the field of cardiovascular interventional treatment devices, in particular, to a double-sided vascular stent with a catalytic release function of nitric oxide and a preparation method thereof. Background technique [0002] Cardiovascular disease has continued to be the number one killer of human health. As one of the important treatments for cardiovascular disease, vascular stent intervention has saved the lives of many patients. [0003] Modification of the vascular stent drug coating by chelated copper ions can promote the release of nitric oxide (NO) from the human body. As an important bioactive factor secreted by endothelial cells, NO plays a vital role in the function of natural vascular endothelial cells. effect. NO has multiple biological functions such as inhibiting platelet adhesion, aggregation and activation, inhibiting smooth muscle cell proliferation, anti-inflammatory, scavenging free radicals, preven...

AI Technical Summary

Problems solved by technology

[0004] At present, NO catalytic coatings based on the coordination of phenolic hydroxyl groups and Cu ions in stent coatings have been widely studied because of the interaction between the phenolic hydroxyl groups and the substrate material. However, the unstable coordination that may exist in such coatings The position will lead to the loss of chelated Cu ions, the coating is not stable and long-lasting, and the repair function of the vascular stent is easily reduced or even disappeared.

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