A preparation method of aminopropyl-3-methylimidazole-based sulfa drugs and their synergists molecularly imprinted polymers

A technology of sulfa drugs and methylimidazole, which is applied in the field of chemical preparation and synthesis, can solve the problems of lack of synchronous detection of sulfa drugs and sulfa synergists, achieve good inclusion and complexation ability and chemical stability, and speed up the synthesis Effect

Active Publication Date: 2021-07-13
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been molecularly imprinted materials for some sulfa drugs, but there is still a lack of molecularly imprinted materials for the simultaneous detection of sulfa drugs and sulfa synergists

Method used

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  • A preparation method of aminopropyl-3-methylimidazole-based sulfa drugs and their synergists molecularly imprinted polymers
  • A preparation method of aminopropyl-3-methylimidazole-based sulfa drugs and their synergists molecularly imprinted polymers
  • A preparation method of aminopropyl-3-methylimidazole-based sulfa drugs and their synergists molecularly imprinted polymers

Examples

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Embodiment 1

[0044] Example 1, Preparation of Template Molecularly Imprinted Polymer Microspheres (MMIP)

[0045] Dissolve 0.200g of sulfadiazine, 0.100g of trimethoprim, 0.500g of MMA, and 0.500g of aminopropyl-3-methylimidazolium bromide in 20mL of acetonitrile+water (20+80), sonicate for 10min, at 25°C Shake for 2 hours to make the template molecules fully react with the functional monomers, then add 2 g of ethylene glycol dimethacrylate and 50 mg of AIBN, and ultrasonicate for 10 min to fully dissolve and mix them, and then pour N into the mixed solution. 2 After 2 minutes, it was sealed and polymerized in a water bath at 60°C for 12 hours to obtain a solid polymer (MIP). The methanol solution with a mass fraction of 10% acetic acid was then used for Soxhlet extraction to elute the template molecules until there were no impurities in the cleaning solution, and then dried at 50° C. for 2 hours to obtain a template molecularly imprinted polymer (MMIP).

[0046] Aminopropyl-3-methylimida...

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Abstract

The invention discloses a preparation method of aminopropyl-3-methylimidazole-based sulfonamides and its synergist molecularly imprinted polymer, which comprises mixing sulfadiazine, trimethoprim and ammonia at room temperature Propyl-3-methylimidazolium bromide and methacrylic acid (MMA) are pre-polymerized in an acetonitrile solution and polymerized in a water bath according to a mass ratio of 2:1:2-10:4-10 to obtain a molecularly imprinted polymer. In the present invention, sulfadiazine and trimethoprim are used as template molecules, and aminopropyl-3-methylimidazolium bromide is added to synthesize and produce molecularly imprinted polymer microspheres for the adsorption properties of sulfa drugs and their synergists. The good adsorption performance of aminopropyl-3-methylimidazolium salt can accelerate the synthesis of molecularly imprinted polymers, change the spatial configuration of molecularly imprinted polymers, and have holes with multiple action points, which can selectively recognize drugs.

Description

technical field [0001] The invention relates to the field of chemical preparation and synthesis, in particular to a method for preparing aminopropyl-3-methylimidazole-based sulfa drugs and their synergist molecularly imprinted polymers. Background technique [0002] Sulphonamides (sulfonamides, SAs) refers to the general term of a class of drugs with p-aminobenzenesulfonamide structure, which is a class of antibiotics used to prevent and treat bacterial infectious diseases; sulfonamide potentiators (SAP) refers to A class of compounds containing 5-substituted benzyl-2,4-diaminopyrimidines, including trimethoprim, dimethoprim, and dimethoxymethoprim, etc., are often used in combination with sulfonamides to make bacteria Folic acid metabolism is double blocked, which can increase the antibacterial effect of sulfonamides. The combination of sulfa drugs and sulfa is not only widely used in the treatment and prevention of animal diseases in the process of animal husbandry, but a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/26G01N30/02G01N30/06G01N30/08G01N30/14B01J20/26B01J20/30
CPCB01J20/268C08F222/1006C08J9/26C08J2201/0424C08J2335/02G01N30/02G01N30/06G01N30/08G01N30/14G01N2030/045G01N2030/126G01N2030/146
Inventor 索德成张苏樊霞李阳肖志明
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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