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Preparation method and application of mica two-dimensional nanosheet as drug carrier

A two-dimensional nano-drug technology, applied in the fields of pharmaceutical formulations, drug combinations, nanotechnology, etc., can solve the problem of no observed adverse reactions in mice and pigs

Pending Publication Date: 2020-03-27
WUHAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this study, no adverse effects were observed in mice and pigs throughout the period of daily mica dosing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of the mica two-dimensional nanosheet (raw material is 1.4 μ m muscovite powder) as drug carrier:

[0053] Weigh 5-10g of polypropylene oxide triamine (Jeffamine T403, abbreviated as T403) and 1-10g of 2,2-bis-(4-glycylamineoxyphenyl)propane (DGEBA), and put them at a certain temperature (0-60℃ ) in mechanical stirring for 1 ~ 6h. Weigh 1.0×10-4~10g of 1.4μm muscovite powder, and grind for 1~3h. Then add ground mica powder and 80-120 mL of distilled water into the 100 mL flask and ultrasonically vibrate for 1-3 hours. When the mixture of T403 and DGEBA turns milky white, add 1~3mL concentrated hydrochloric acid to acidify and stir for 5~20min, then add it to the sonicated mica suspension, and mechanically stir the mixture at 60~100℃ for 2~8h . Use 100-200mL of ethanol / water mixture at a centrifugal speed of at least 6000rpm for at least 15 minutes to remove polyamine, then obtain a supernatant at a centrifugal speed of 500-2000rpm, and dry it a...

Embodiment 2

[0056] The preparation method of the mica two-dimensional nanosheet (raw material is 1.6 μ m muscovite powder) as drug carrier:

[0057] Weigh 5-10g of polypropylene oxide triamine (Jeffamine T403, abbreviated as T403) and 1-10g of 2,2-bis-(4-glycylamineoxyphenyl)propane (DGEBA), and put them at a certain temperature (0-60℃ ) in mechanical stirring for 1 ~ 6h. Weigh 1.0×10-4~10g of 1.6μm muscovite powder, and grind for 1~3h. Then add ground mica powder and 80-120 mL of distilled water into the 100 mL flask and ultrasonically vibrate for 1-3 hours. When the mixture of T403 and DGEBA turns milky white, add 1~3mL concentrated hydrochloric acid to acidify and stir for 5~20min, then add it to the sonicated mica suspension, and mechanically stir the mixture at 60~100℃ for 2~8h . Use 100-200mL of ethanol / water mixture at a centrifugal speed of at least 6000rpm for at least 15 minutes to remove polyamine, then obtain a supernatant at a centrifugal speed of 500-2000rpm, and dry it a...

Embodiment 3

[0060] A preparation method of a mica two-dimensional nanosheet drug carrier containing drug components (the tumor treatment drug is doxorubicin hydrochloride):

[0061] Weigh 5-10g of polypropylene oxide triamine (Jeffamine T403, abbreviated as T403) and 1-10g of 2,2-bis-(4-glycylamineoxyphenyl)propane (DGEBA), and put them at a certain temperature (0-60℃ ) in mechanical stirring for 1 ~ 6h. Weigh 1.0×10-4~10g of 1.6μm muscovite powder, and grind for 1~3h. Then add ground mica powder and 80-120 mL of distilled water into the 100 mL flask and ultrasonically vibrate for 1-3 hours. When the mixture of T403 and DGEBA turns milky white, add 1~3mL concentrated hydrochloric acid to acidify and stir for 5~20min, then add it to the sonicated mica suspension, and mechanically stir the mixture at 60~100℃ for 2~8h . Use 100-200mL of ethanol / water mixture at a centrifugal speed of at least 6000rpm for at least 15 minutes to remove polyamine, then obtain a supernatant at a centrifugal s...

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Abstract

The invention provides a mica two-dimensional nanosheet as a drug carrier, and a preparation method of a mica two-dimensional nanosheet drug carrier containing a drug component. The low long-term toxicity, good biocompatibility and good biodegradability of mica are used, so that the mica two-dimensional nanosheet drug carrier containing a drug component can reduce multidrug resistance and systemictoxicity, and has pH-responsive drug release and selective cytotoxicity. Compared with a non-exfoliated mica powder, the mica two-dimensional nanosheet drug carrier containing a drug component has asmaller particle size, and is more easily swallowed by tumor cells.

Description

technical field [0001] The present invention relates to the preparation process of mica two-dimensional nano-sheet material, and also relates to the preparation method of mica two-dimensional nano-sheet drug-carrier containing drug components, which can be applied to cancer chemotherapy, photodynamic therapy, photothermal and immunotherapy Combined therapy. Background technique [0002] Inorganic nanomaterials show greater potential for future clinical translation due to their intrinsic features such as easy functionalization, tunable structure and morphology, ideal biocompatibility, and relatively high physiological stability. More importantly, the unique physicochemical properties of inorganic nanomaterials endow them with excellent therapeutic effects in oncology applications. Two-dimensional (2D) inorganic nanosheets with unique planar morphologies have attracted great attention from the scientific community in recent years. Owing to their two-dimensional morphological...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/02A61K45/00A61P35/00B82Y5/00
CPCA61K9/143A61K45/00A61P35/00B82Y5/00
Inventor 邹涛夏甜刘秀然李游雷灿杨晓艳
Owner WUHAN UNIV OF SCI & TECH
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