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Chloroquine antibacterial disinfectant and application thereof

A technology of disinfectant and chloroquine, which is applied in the fields of application, disinfectant, antibacterial, etc., can solve the problems of research and reports on the lack of chloroquine disinfection and antibacterial cleaning products, and achieve the effect of broad application prospects

Active Publication Date: 2020-03-27
广州康健医学科技有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in order to meet the needs of antibacterial and disinfection for daily cleaning, including antiviral cleaning and cleaning products that can inhibit the new coronavirus (2019-nCoV), there are currently no related products on the market, and there are no chloroquine-based disinfection and antibacterial cleaning products research and reports

Method used

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  • Chloroquine antibacterial disinfectant and application thereof
  • Chloroquine antibacterial disinfectant and application thereof
  • Chloroquine antibacterial disinfectant and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 13

[0067] The antibacterial effect of embodiment 1 3% chloroquine phosphate medicinal liquid

[0068] 1. Make chloroquine phosphate into an in vitro disinfection solution with a mass concentration of 3%, the solvent is purified water, and the pH is adjusted to 7.0 with citric acid.

[0069] 2. Antibacterial effect test of chloroquine phosphate liquid

[0070] Add 20ml of the above liquid product into the pH 7.0 buffer solution (the negative control does not add the test product liquid, that is, the blank group) to fully dissolve it. Then take 1 mL, 0.5 mL, 0.25 mL and 0.125 mL respectively and add them into the culture medium corresponding to the corresponding bacterial species, and culture them in a plate. Pseudomonas aeruginosa, Candida albicans, Escherichia coli, and Staphylococcus aureus were resuscitated and diluted. When the bacterial concentration was 100 cfu / mL, the inoculation loop was inoculated into each medium, and observation began after 5 to 7 days of cultivation. ...

Embodiment 2

[0076] The same method as in Example 1 was used to prepare medicinal liquids with different concentrations, and the pH values ​​were all adjusted to 7.0. With the bacteriostasis test method of embodiment 1, test the bacteriostasis of each medicinal liquid of 0.25ml. The results are shown in Table 2.

[0077] Table 2

[0078]

Embodiment 2

[0079] Embodiment 2 The influence of the pH value of the medicinal solution on the antibacterial effect

[0080] The method of reference example 1 prepares respectively the 3% chloroquine phosphate medicinal liquid of different pH, with the bacteriostasis test method of embodiment 1, test the bacteriostatic effect of each medicinal liquid of 0.25ml. The results are shown in Table 3. The results showed that acidic conditions were more conducive to the antibacterial effect of chloroquine phosphate.

[0081] table 3

[0082]

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Abstract

The invention discloses a chloroquine antibacterial disinfectant and application thereof. Chloroquine or a chloroquine derivative with the mass concentration of 0.1-5.0% is used as a main effective component, and the pH value is 4.0-7.0. Furthermore, plant extracts which are derived from natural plants and have a bactericidal effect can be supplemented, and an obvious synergistic effect is achieved on the bacteriostatic and antiviral effects of chloroquine. The liquid medicine has a certain cleaning and killing effect on various bacteria and viruses, especially on spreading and infection of coronavirus, HPV, HIV and other viruses and bacteria, and has a very good effect on prevention of oral cavity, home environment, exposed skin and other bacteria and virus susceptible parts. Moreover, chloroquine is developed into an external disinfection preparation and can be further developed into various sanitary disinfection products and old medicines for new use, compared with similar disinfection products, the external disinfection preparation can be orally taken and is small in harm, people can be more effectively protected against germs and viruses when the external disinfection preparation is sold on the market, and the external disinfection preparation is wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of antibacterial and disinfection products. More specifically, it relates to a bacteriostatic disinfectant containing chloroquine or chloroquine derivatives and applications thereof. Background technique [0002] With the improvement of people's living standards and the deepening of understanding of microorganisms, people pay more and more attention to personal hygiene in daily life. Since December 2019, the outbreak of novel coronavirus (2019-nCoV) pneumonia / lung infection that originated in Wuhan City, Hubei Province has been aggravating. Public health emergencies (PHEIC). This incident has made people pay more attention to and pay more attention to the daily antibacterial and antiviral work. [0003] Cleaning and care products with antibacterial effect, such as mouthwash, hand sanitizer, disinfectant wipes, etc., have a very good effect on the daily protection of germs and viruses. And present similar...

Claims

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Application Information

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IPC IPC(8): A61K31/4706A61K31/353A61K36/8962A61K36/815A61K36/28A61P31/02A61P31/04A61P31/12A61P31/14A61P31/18A01N43/42A01N43/16A01N65/42A01N65/38A01N65/12A01P1/00
CPCA01N43/16A01N43/42A01N65/00A01N65/12A01N65/38A01N65/42A61K31/353A61K31/4706A61K36/28A61K36/815A61K36/8962A61P31/02A61P31/04A61P31/10A61P31/12A61K2300/00
Inventor 王建瑜谢龙旭李相玲袁曼莉王婷胡博
Owner 广州康健医学科技有限公司
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