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Composite, tissue repair material and preparation method and application thereof

A tissue repair and complex technology, which can be applied to other methods of inserting foreign genetic materials, unknown raw materials, drug combinations, etc. The effect of promoting angiogenesis and promoting tissue repair ability

Active Publication Date: 2022-07-19
SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although artificially synthesized liposomes are convenient for modifying functional groups, the cost is greatly increased, and the synthesis process is more cumbersome, and liposomes are derived from foreign substances, the human body has limited tolerance, and it is easy to generate immune reactions in the body

Method used

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  • Composite, tissue repair material and preparation method and application thereof
  • Composite, tissue repair material and preparation method and application thereof
  • Composite, tissue repair material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] An embodiment of the present invention provides a complex, the complex is formed by combining a targeting group and a medicinal vesicle, the targeting group is selected from aptamers, and the medicinal vesicle is selected from exosomes body.

[0173] The embodiment of the present invention utilizes the targeting effect of aptamers on specific cells, so that exosomes migrate and act on target cells, improve the bioavailability of exosomes, and achieve the purpose of promoting tissue repair. Aptamer-modified exosomes can accelerate the growth and migration of fibroblasts from chronic non-healing wounds, and can effectively activate growth factor signaling pathways, increase the expression of angiogenesis-related genes and matrix proteins, and induce the formation of new blood vessels Therefore, the complex provided by the present invention can be used as a safe and effective product to promote the healing of chronic refractory wounds or bone defects.

[0174] In some emb...

Embodiment 2

[0210] This example provides a composition whose active ingredient is the complex described in Example 1. The composition of the present invention can accelerate the growth and migration of fibroblasts from chronic non-healing wounds, and can effectively activate growth factor signaling pathways, improve the expression of angiogenesis-related genes and matrix proteins, and induce the formation of new blood vessels or osteoblasts. Therefore, the composition provided by the present invention can be used as a safe and effective product to promote the healing of chronic refractory wounds or bone defects.

Embodiment 3

[0212] This example provides the use of the complex of Example 1 or the composition of Example 2 in promoting angiogenesis. The blood vessels include arterial blood vessels, venous blood vessels and capillaries. The capillaries include capillaries existing in the dermis of the skin, bone tissue, and cardiomyocytes.

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Abstract

The present invention provides a complex, a tissue repair material and a preparation method and application thereof. The complex has stable medicinal effect, high targeting, high delivery efficiency, good tolerance in vivo, and can be passed through endogenous The organisms perform a variety of biological functions while avoiding immune responses in the body. The tissue repair material has stable therapeutic effect and targeting in the treatment of skin diseases, especially in the treatment of long-term incurable diabetic complications.

Description

technical field [0001] The invention belongs to the technical field of biological products, and in particular relates to a composite body, a tissue repair material and a preparation method and application thereof. Background technique [0002] The damage or dysfunction of tissues and organs is one of the major hazards to human health and the most important cause of human disease and death. At present, there are three common tissue and organ defect repair techniques in clinic: allogeneic tissue transplantation, but there are problems of histocompatibility and serious shortage of donor sources; autologous tissue transplantation, which sacrifices normal tissue and has heterotopic tissue. Often lead to functional disorders; the application of synthetic material substitutes, easily lead to foreign body reaction, secondary infection and surrounding tissue atrophy. [0003] Mesenchymal stem cells are an important member of the stem cell family. They originate from the mesoderm in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/88
CPCA61K35/28A61K47/549A61K47/60A61P17/02A61P19/08A61P3/10C08G65/33337C08G65/33306
Inventor 胡成虎赵娜
Owner SHAANXI BIO REGENERATIVE MEDICINE CO LTD
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