Xiaoer Resuqing granule flavoring composition, its granule and its preparation method

Abstract

The invention relates to an infant heat-clearing granule corrective composition, a granule and a preparation method of the granule. The corrective composition consists of a bulk drug and composition auxiliary materials, and is capable of effectively improving bitter taste of the infant heat-clearing composition by adding steviosin, orange essence and cane sugar. The composition is added with pregel starch and sodium 4-aminobenzoate for preparing the granule, and the stability and the dissolution property of the granule are improved. Also by preparing a micro-capsule from main bitter compositions of the infant heat-clearing granule, such as radix et rhizoma rhei and radix scutellariae, and special auxiliary materials, the bitter taste of the granule is further masked, the medicine can be continuously released, and the medicine administration frequency is less.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a Xiaoer Resuqing flavor correction composition, granules and a preparation method thereof. Background technique [0002] Pediatric Resuqing is currently one of the most commonly used medicines for treating children with colds; it has the functions of clearing heat, detoxifying, and relieving throat; it is mainly used for wind-heat cold, fever and headache, sore throat, cough, and constipation. [0003] The oral preparations of Xiaoer Resuqing that have been marketed include granules, oral liquids, and syrups. These existing preparations generally have technical problems such as poor absorption, low bioavailability, or relatively slow onset of action, which brings great harm to children. Inconvenience; Among them, granules are widely studied due to their convenience and quick onset of action. [0004] The applicant has obtained Xiaoer Resuqing Gra...

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Problems solved by technology

[0003] The oral preparations of Xiaoer Resuqing that have been marketed include granules, oral liquids, and syrups. These existing preparations generally have technical problems such as poor absorption, low bioavailability, or relatively slow onset of action, which brings great harm to children. Inconvenient; among them, granules are convenient to take and take effect quickly, so the current research on granules is relatively extensive

[0004] The applicant has obtained Xiaoer Resuqing Granules on the market, the main components of which are Bupleurum 1250g, Scutellaria baicalensis 625g, Radix Isatidis 1250g, Pueraria 625g, Honeysuckle 687.5g, Buffalo horn 312.5g, Forsythia 750g and Rhubarb 312.5g; Production and sales have shown that Xiaoer Resuqing Granules have many excellent features, including convenience in taking medicine, and have been recognized by the majority of users; however, after research, it is also found that the original prescription has some shortcomings, mainly: 1) The taste is not ideal, due to the The raw materials of Resuqing are traditional Chinese medicine ingredients. Several medicinal materials such as rhubarb, scutellaria, Bupleurum and Radix Radix are all bitter traditional Chinese medicines, which are difficult to accept for children; 2) the solubility is not good, because the extraction process The extract is bonded into deep-colored and hard particles, and its solubility is relatively poor. After being made into granules, there are still drugs that cannot be dissolved and float on the water surface, which may easily lead to inaccurate dosages for patients; the reason is that some traditional Chinese medicine ingredients For example, baicalin, the main component of Scutellaria baicalensis, has poor water solubility and stability, and is easily destroyed by the pH value of the solution; 3) Although granule granules are easier for children to accept, their stability is poor and their efficacy is poor. The fast release leads to more frequent administration, which is extremely difficult for children who have difficulty in feeding the medicine; the above factors all affect the clinical application of Xiaoer Resuqing Granules

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