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Double-layer buccal tablet for oral health and preparation method thereof

A buccal tablet and double-layer technology, which is applied in the field of oral cleaning, can solve the problems of poor consumer acceptance, time and place restrictions, and weak cleaning effect, so as to balance the oral micro-ecological environment, inhibit the growth of harmful oral bacteria, and clean the mouth. strong effect

Active Publication Date: 2020-03-31
成都三勒浆药业集团四川华美制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the weak cleaning effect, poor consumer acceptance, and time and place limitations in the prior art products for cleaning the tongue coating, the present invention provides a double-layer buccal tablet for oral health and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] probiotic lozenges

[0070] A probiotic buccal tablet beneficial to oral health, the buccal tablet comprises a double-layer structure composed of a rough layer and a smooth layer, and the weight ratio of the rough layer and the smooth layer is 1:2. The rough layer is made of 98 parts of mixed sugar alcohol (sorbitol:erythritol=3:2), 0.2 part of steviol glycoside, 0.3 part of refreshing essence, 0.7 part of mint essence, and 0.8 part of magnesium stearate; The smooth layer consists of 90 parts of sorbitol, 0.5 part of Lactobacillus salivarius, 0.5 part of Bifidobacterium lactis, 0.5 part of Lactobacillus plantarum, 0.5 part of Lactobacillus casei, 1 part of lemon flavor, 6.2 parts of microcrystalline cellulose, stearic acid 0.8 parts of magnesium.

[0071] The above-mentioned probiotic buccal tablet beneficial to oral health is prepared by the following method:

[0072] S1. According to the ratio of 98 parts of mixed sugar alcohols, 0.2 parts of steviol glycosides, 0....

Embodiment 2

[0077] fruit flavor lozenges

[0078] The fruit-flavored buccal tablet beneficial to oral health has a double-layer sheet structure, which is the first layer and the second layer. Among them, the first layer of tablets is made of 98 parts of mixed sugar alcohol (sorbitol: erythritol = 3:2), 0.2 part of steviol glycoside, 0.3 part of refreshing flavor, 0.7 part of mint flavor, and 0.8 part of magnesium stearate The second layer sheet is made of 82 parts of sorbitol, 10 parts of passion fruit powder, 1 part of passion fruit essence, 6.2 parts of microcrystalline cellulose, and 0.8 part of magnesium stearate.

[0079] The preparation method of the above-mentioned fruit-flavored buccal tablets, the fruit-flavored buccal tablets beneficial to oral health is as follows:

[0080]S1. According to the proportions by weight of 98 parts of mixed sugar alcohol, 0.2 part of steviol glycoside, 0.3 part of refreshing essence, 0.7 part of mint essence, and 0.8 part of magnesium stearate, a...

Embodiment 3

[0085] tea flavor lozenges

[0086] The tea-flavored buccal tablet beneficial to oral health has a double-layer tablet structure consisting of a rough layer and a smooth layer. Among them, the rough layer is made of 98 parts of mixed sugar alcohol (sorbitol: erythritol = 3:2), 0.2 part of steviol glycoside, 0.3 part of refreshing essence, 0.7 part of mint essence, and 0.8 part of magnesium stearate; The layer is made of 82 parts of sorbitol, 10 parts of jasmine tea powder, 1 part of jasmine essence, 6.2 parts of microcrystalline cellulose and 0.8 part of magnesium stearate.

[0087] The above-mentioned tea-flavored buccal tablet beneficial to oral health is prepared by the following method:

[0088] S1. Weigh a total of 110 g of materials according to the proportions by weight of 98 parts of mixed sugar alcohol, 0.2 part of steviol glycoside, 0.3 part of refreshing essence, 0.7 part of mint essence, and 0.8 part of magnesium stearate, and mix them uniformly to obtain the fi...

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Abstract

The invention discloses a double-layer buccal tablet for oral health, one surface of the buccal tablet is a rough layer, and the other surface of the buccal tablet is a smooth layer; wherein the roughlayer is prepared by mixed sugar alcohol; the smooth layer is of a layered structure prepared by auxiliary materials. The preparation method comprises the following steps: S1, uniformly mixing raw materials of the rough layer in proportion to obtain a first mixture; uniformly mixing the raw materials of the smooth layer in proportion to obtain a second mixture; step S2, pressing the first mixtureobtained in the step S1 into tablets under the pressure of 1-5kg / cm <2> to obtain pre-pressed tablets; and S3, pressing the second mixture on the pre-pressed tablets obtained in the step S2, and performing pressing under the pressure of 10-15kg / cm <2> so as to obtain the double-layer buccal tablets. The double-layer buccal tablet disclosed by the invention has a strong tongue coating cleaning effect, can effectively inhibit breeding of oral harmful bacteria and balance the oral micro-ecological environment, is convenient to carry, is not limited by time and place, and is easily accepted by common consumers.

Description

technical field [0001] The invention relates to the technical field of oral cavity cleaning, in particular to a double-layer buccal tablet for oral health and a preparation method thereof. Background technique [0002] Oral health is an important part of human health and an important symbol reflecting the physical and mental health and civilization level of residents in a country or region. However, the current situation of oral health of Chinese residents is worrying. Residents have very serious oral problems, such as bad breath, dental caries, periodontal disease, oral mucosal disease, tooth allergies, oral tumors and other prominent problems. Oral health status is closely related to various factors such as personal eating habits, oral health behaviors, and utilization of oral health services. On the one hand, due to changes in people's lifestyles and dietary structures, the intake of refined sugary foods such as cakes and biscuits and sugary drinks has increased, resulti...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/34A61K8/99A61K8/73A61K8/9789A61K8/9794A61P1/02A61P31/02A23L29/30A23L33/135A23L33/105A23F3/32A23F3/40A23F3/34A23P10/28A23P20/20
CPCA61K8/0233A61K8/345A61K8/99A61K8/73A61K8/9789A61K8/9794A61P1/02A61P31/02A23L29/37A23L33/135A23L33/105A23F3/32A23F3/405A23F3/34A23P10/28A23P20/20A23V2002/00A23V2400/181A23V2400/125A23V2400/169A23V2200/30A23V2200/3204A23V2250/21A23V2250/262A23V2250/642A23V2250/6402A23V2250/51084
Inventor 刘海燕宋昱罗明锋郑有德杜志琳莫芳黄辉陈丽璇莫太刚李再兴樊三虎
Owner 成都三勒浆药业集团四川华美制药有限公司
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