Use of uterine cavity fluid-derived exosomes in the preparation of infertility-related disease treatment drugs and adjuvant therapeutics

A technology for infertility and disease treatment, applied in the direction of diseases, drug combinations, microorganisms, etc., can solve the problems of unspecified use of exosomes, application research of exosomes without source, etc., to achieve good therapeutic effect, The preparation process is simple and the effect of enhancing developmental potential
CN110946878BActive Publication Date: 2021-10-12PHARCHOICE THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PHARCHOICE THERAPEUTICS INC
Publication Date
2021-10-12

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Abstract

The invention relates to the field of medical technology, and provides the use of exosomes derived from uterine cavity fluid in the preparation of drugs and auxiliary therapeutic agents for infertility-related diseases. It has been confirmed by experiments that exosomes can achieve endometrial growth disorder by promoting the increase of endometrial thickness, enhancing endometrial cell viability, reducing endometrial cell damage, promoting VEGF expression, maintaining endometrial stromal cell stemness and stimulating proliferation. Treatment or remission of diseases; by exerting the role of immune tolerance, treating spontaneous abortion, and increasing the level of T helper lymphocytes, the treatment or remission of diseases related to maternal-fetal immune tolerance disorder is realized, which provides a new method for infertility treatment Theoretical basis. In addition, the exosomes of the present invention can effectively increase the development rate of fertilized eggs fertilized in vivo or fertilized eggs in vitro, and at the same time improve the implantation rate and litter rate of in vitro fertilization rate transplantation , Play a positive auxiliary role in the treatment of infertility.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to the use of exosomes derived from uterine cavity fluid in the preparation of drugs and auxiliary therapeutic agents for infertility-related diseases, a preparation method of the exosomes, and a pharmaceutical composition containing the exosomes . Background technique

[0002] The endometrial injury is mainly the injury of the endometrial basal layer, which is mainly related to curettage during pregnancy. Compared with the normal endometrium, the endometrial basal layer during pregnancy is loose and more susceptible to damage. Based on my country's national conditions and the increasing rate of induced abortion, the occurrence of endometrial damage cannot be ignored. The endometrial basal layer is damaged, which may lead to damage or loss of endometrial stem cells; at the same time, local infection and aseptic inflammation of the injured endometrium can destroy the niche microenvironment ...

Claims

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