Preparation and application of antibacterial modified exosome burn wound healing-promoting biological dressing

A biological dressing and exosome technology, which is applied in drug delivery, medical science, absorbent pads, etc., can solve the problems of exosomes lack of antibacterial function and limited effect, and achieve the promotion of wound healing, good wound healing, and good air permeability Effect
CN110975000AInactive Publication Date: 2020-04-10BEIHANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIHANG UNIV
Publication Date
2020-04-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

Preparation and application of an antibacterial modified exosome burn wound healing-promoting biological dressing are disclosed. A raw dressing is a novel artificially modified exosome prepared by taking cell-derived exosome as a carrier of an antibacterial agent and combining with a broad-spectrum antibacterial agent; and the modified exosome is loaded into an asymmetric chitosan porous moisturizing dressing. The weight ratio of chitosan to water-absorbing molecules to the exosome to the antibacterial agent in the dressing is (40-60): (20-40): (5-20): (1-10). The dressing has a broad-spectrumantibacterial effect, a blood vessel repair promoting effect, a nerve repair promoting effect and a wound healing promoting effect. Meanwhile, the dressing has moisture retention, air permeability, barrier property, high strength and easy disclosure, and is a novel antibacterial compound dressing with a broad-spectrum antibacterial effect. The dressing is prepared through freeze-drying, has advantages of simple preparation process, low cost, outstanding treatment effect and good safety, and has remarkable medical value and industrialization potential.
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Description

technical field

[0001] The invention relates to an antibacterial modified exosome burn wound healing-promoting biological dressing, in particular to a water-absorbing antibacterial and healing-promoting hydrogel antibacterial dressing for infectious wounds. Background technique

[0002] The skin is the largest organ of the human body. It not only protects the body from damage, isolates pathogens, and acts as a barrier protection, but also plays an important role in preventing excessive water loss from the body. Trauma often damages normal skin tissue structure and physiological functions. The infection caused by the wound during the treatment process has always been the main problem in the clinical treatment process. Pseudomonas aeruginosa (P. aeruginosa, a typical Gram-negative bacterium) is a widely distributed microorganism in nature, and it is also one of the main pathogens of nosocomial infection. Wound infection caused by Pseudomonas aeruginosa invasion into the woun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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